Michael F. Moody
Structural Biology Using Electrons and X-rays: An Introduction for Biologists
# ISBN 13: 9780123705815

*Structural Biology Using Electrons and X-rays* is the perfect book to provide advanced undergraduates or graduate students with an accessible introduction to the two major diffraction-based techniques of structural biology. While concentrating on electron cryo-microscopy with image analysis, it also includes X-ray crystallography in a coherent survey of fundamental principles. Starting with Fourier transforms and progressing through optics and imaging principles, symmetry and three-dimensional reconstruction theory, *Structural Biology Using Electrons and X-rays* ends in an account of the latest methods adapted to crystals, helices, viral heads, and single particles.

- Emphasis on common principles underlying all diffraction-based methods
- Thorough grounding in theory requires understanding of only simple algebra
- Visual representations and explanations of challenging content
- Mathematical detail offered in short-course form to parallel the text

*"synopsis" may belong to another edition of this title.*

To understand cell functions we need to know many macromolecular structures, which we get with sophisticated physical techniques: X-ray diffraction, electron cryo-microscopy, and NMR. Fourier transforms (FTs) are used in all three, but especially in the first two which calculate molecular images. Unfortunately, FT mathematics is not included in ordinary biology courses, adding to the difficulty of finding 3D biomolecular structures.

This book aims to make FTs (and other relevant mathematics) as comprehensible as possible, by replacing equations with intuitive methods that use diagrams. These methods are then employed for explaining the first two structural techniques--particularly electron microscopy--covering both the classical methods appropriate for symmetrical structures and the more modern "single particle" methods.

--Michael Moody

This book, suitable for advanced undergraduates or graduate students, provides an accessible introduction to the two major diffraction-based techniques of structural biology. While concentrating on electron cryo-microscopy with image analysis, it also includes X-ray crystallography in a coherent survey of fundamental principles. Starting with Fourier transforms and progressing through optics and imaging principles, symmetry and three-dimensional reconstruction theory, *Structural Biology Using Electrons and X-rays* ends in an account of the latest methods adapted to crystals, helices, viral heads, and single particles.

Key features:

-Emphasis on common principles underlying all diffraction-based methods

-Thorough grounding in theory requires understanding of only simple algebra

-Visual representations and explanations of challenging content

-Mathematical detail offered in short-course form to parallel the text

Michael Moody has worked in leading laboratories in the United States and Europe and taught at many international electron-microscopy image-analysis courses.

*"About this title" may belong to another edition of this title.*

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(2011)

ISBN 10: 0123705819
ISBN 13: 9780123705815

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**Book Description **Elsevier Science Publishing Co Inc, United States, 2011. Paperback. Book Condition: New. 231 x 188 mm. Language: English . Brand New Book. Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance (NMR), which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier transforms, as well as the different methods used for image processing using X-ray crystallography and the analysis of electron micrographs. Part 5 focuses entirely on the mathematical aspect of Fourier transforms. In addition, the book examines detailed structural analyses of a specimen s symmetry (i.e., crystals, helices, polyhedral viruses and asymmetrical particles). This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance (NMR). It is also suitable for readers without a background in physical chemistry or mathematics. *Emphasis on common principles underlying all diffraction-based methods *Thorough grounding in theory requires understanding of only simple algebra *Visual representations and explanations of challenging content *Mathematical detail offered in short-course form to parallel the text. Bookseller Inventory # AA59780123705815

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Published by
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ISBN 10: 0123705819
ISBN 13: 9780123705815

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**Book Description **Elsevier Science Publishing Co Inc, United States, 2011. Paperback. Book Condition: New. 231 x 188 mm. Language: English . Brand New Book. Structural Biology Using Electrons and X-Rays discusses the diffraction and image-based methods used for the determination of complex biological macromolecules. The book focuses on the Fourier transform theory, which is a mathematical function that is computed to transform signals between time and frequency domain. Composed of five parts, the book examines the development of nuclear magnetic resonance (NMR), which allows the calculation of the images of a certain protein. Parts 1 to 4 provide the basic information and the applications of Fourier transforms, as well as the different methods used for image processing using X-ray crystallography and the analysis of electron micrographs. Part 5 focuses entirely on the mathematical aspect of Fourier transforms. In addition, the book examines detailed structural analyses of a specimen s symmetry (i.e., crystals, helices, polyhedral viruses and asymmetrical particles). This book is intended for the biologist or biochemist who is interested in different methods and techniques for calculating the images of proteins using nuclear magnetic resonance (NMR). It is also suitable for readers without a background in physical chemistry or mathematics. *Emphasis on common principles underlying all diffraction-based methods *Thorough grounding in theory requires understanding of only simple algebra *Visual representations and explanations of challenging content *Mathematical detail offered in short-course form to parallel the text. Bookseller Inventory # AA59780123705815

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