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Perfusion de Cisplatine Hypotonique Dans Le Foie Isole

Olivier Facy

Published by Presses Academiques Francophones
ISBN 10: 3838178947 / ISBN 13: 9783838178943
New / Paperback / Quantity Available: 20
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Title: Perfusion de Cisplatine Hypotonique Dans Le ...

Publisher: Presses Academiques Francophones

Binding: Paperback

Book Condition: New

Book Type: Paperback

Description:

Paperback. 80 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.La rsection est le seul traitement curatif des tumeurs du foie, mais seul un tiers des patients est ligible la chirurgie. La perfusion de chimiothrapie dans le foie isol de la circulation gnrale permettrait de dlivrer de fortes doses de drogue en labsence de toxicit systmique. Le cisplatine a montr une meilleure pntration intracellulaire et une forte activit en milieu hypotonique. Cette tude exprimentale sur 10 porcs a consist en une perfusion de cisplatine hypotonique sur foie isol, grce un circuit ouvert entrant par la veine porte et sortant par la veine cave infrieure. En 30 minutes, 3 L de cisplatine en milieu hypotonique ont t perfuss. La tolrance per-opratoire a t bonne grce un clampage aortique intermittent. Les quantits de cisplatine doses dans la circulation gnrale taient minimes, confirmant lefficacit de lexclusion. Il ny a eu aucune toxicit systmique. La toxicit histologique hpatique existait aux concentrations de 100 et 75 mgL, mais pas 50 mgL. Lexposition in vitro des cellules cancreuses humaines hyper-rsistantes a montr une cytotoxicit de 90, signe dune forte activit antitumorale in vitro. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783838178943

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