9780815340782

The Biology of Cancer

Weinberg, Robert A.

ISBN 10: 0815340788 / 0-8153-4078-8
ISBN 13: 9780815340782
Publisher: Garland Science
Publication Date: 2006
Binding: Hardcover
Editorial Reviews for this title:
Synopsis:

The Biology of Cancer is a textbook for undergraduate and graduate biology students as well as medical students studying the molecular and cellular bases of cancer. The book presents the principles of cancer biology in an organized, cogent, and in-depth manner. The clarity of writing and the lucid full-color art program make the book accessible and engaging. The information unfolds through the presentation of key experiments which give readers a sense of discovery and provides insights into the conceptual foundation underlying modern cancer biology.

The Biology of Cancer synthesizes the findings of three decades of recent cancer research and proposes a conceptual framework from which to teach about these discoveries. It provides the necessary structure, organization, and content for a course on cancer biology for advanced undergraduates and beginning doctoral students. The book is comprehensive and offers many pedagogical features to assist teaching and learning. The book includes many recent and topical references, and is intended to empower the student to move directly into the primary research literature.

The text is up-to-date and provides current information on topics such as tumor stem cells and recently introduced chemotherapeutics. State-of-the-art techniques are discussed throughout. Modern biomedical research is explored, helping readers to hone their analytical abilities and to assimilate and think clearly about complex biological processes. The Biology of Cancer provides insights into many aspects of immunology, developmental biology, and neurobiology.

The exceptional full-color art program contains many images published for the first time. The book is extensively illustrated with schematic drawings, micrographs, computer-generated models and graphs. The pieces were chosen to support and clarify the concepts, as well as to supply additional interest.

Besides its value as a textbook, The Biology of Cancer will be a useful reference for individuals working in biomedical laboratories, and for clinical professionals.


Editorial reviews may belong to another edition of this title.
 

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Weinberg, Robert A.
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Book Description: Garland Science, 2006. Hardcover. Book Condition: Brand New. 1st edition. 796 pages. 10.75x8.50x1.25 inches. In Stock. Bookseller Inventory # zk0815340788

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Book Description: Garland Science, 2006. Book Condition: New. Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: Preface Chapter 1 The Biology and Genetics of Cells and Organisms 1.1 Mendel establishes the basic rules of genetics 1.2 Mendelian genetics helps to explain Darwinian evolution 1.3 Mendelian genetics governs how both genes and chromosomes behave 1.4 Chromosomes are altered in most types of cancer cells 1.5 Mutations causing cancer occur in both the germ-line and the soma 1.6 Genotype embodied in DNA sequences creates phenotype through proteins 1.7 Gene expression patterns also control phenotype 1.8 Transcription factors control gene expression 1.9 Metazoa are formed from components conserved over vast evolutionary time periods 1.10 Gene cloning techniques revolutionized the study of normal and malignant cells Chapter 2 The Nature of Cancer 2.1 Tumors are complex tissues 2.2 Tumors arise from many specialized cell types throughout the body 2.3 Some types of tumors do not fit into the major classifications 2.4 Cancers seem to develop progressively 2.5 Tumors are monoclonal growths 2.6 Cancers occur with vastly different frequencies in different human populations 2.7 The risks of cancers often seem to be increased by assignable influences including lifestyle 2.8 Specific chemical agents can induce cancer 2.9 Both physical and chemical carcinogens act as mutagens 2.10 Mutagens may be responsible for some human cancers 2.11 Synopsis and prospects Essential Concepts Additional Reading Chapter 3 Tumor viruses 3.1 Peyton Rous discovers a chicken sarcoma virus 3.2 Rous sarcoma virus is discovered to transform infected cells in culture 3.3 The continued presence of RSV is needed to maintain transformation 3.4 Viruses containing DNA molecules are also able to induce cancer 3.5 Tumor viruses induce multiple changes in cell phenotype including acquisition of tumorigenicity 3.6 Tumor virus genomes persist in virus-transformed cells by becoming part of host cell DNA 3.7 Retroviral genomes become integrated into the chromosomes of infected cells 3.8 A version of the src gene carried by RSV is also present in uninfected cells 3.9 RSV exploits a kidnapped cellular gene to transform cells 3.10 The vertebrate genome carries a large group of proto-oncogenes 3.11 Slowly transforming retroviruses activate proto-oncogenes by inserting their genomes adjacent to these cellular genes 3.12 Some retroviruses naturally carry oncogenes 3.13 Synopsis and prospects Essential Concepts Additional Reading Chapter 4 Cellular oncogenes 4.1 Can cancers be triggered by the activation of endogenous retroviruses? 4.2 Transfection of DNA provides a strategy for detecting nonviral oncogenes 4.3 Oncogenes discovered in human tumor cell lines are related to those carried by transforming retroviruses 4.4 Proto-oncogenes can be activated by genetic changes affecting either protein expression or structure 4.5 Variations on a theme: the myc oncogene can arise via at least three additional distinct mechanisms 4.6 A diverse array of structural changes in proteins can also lead to oncogene activation 4.7 Synopsis and prospects Essential Concepts Additional Reading Chapter 5 Growth factors and their receptors 5.1 Normal metazoan cells control each other's lives 5.2 The Src protein functions as a tyrosine kinase 5.3 The EGF receptor functions as a tyrosine kinase 5.4 An altered growth factor receptor can function as an oncoprotein 5.5 A growth factor gene can become an oncogene: the case of sis 5.6. Transphosphorylation underlies the operations of receptor tyrosine kinases 5.7 Yet other types of receptors enable mammalian cells to communicate with their environment 5.8 Integrin receptors sense association between the cell and the extracellular matrix 5.9 The Ras protein, an apparent component of the downstream signaling cascade, functions as. Bookseller Inventory # ABE_book_new_0815340788

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