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9781429203142

Molecular Cell Biology

Lodish, Harvey; Berk, Arnold; Kaiser, Chris A.; Krieger, Monty; Scott, Matthew P.; Bretscher, Anthony; Ploegh, Hidde; Matsudaira, Paul T.

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9781429203142: Molecular Cell Biology

With its acclaimed author team, cutting-edge content, and coverage based on landmark experiments, Molecular Cell Biology has earned an impeccable reputation with instructors, edition after edition. The new Sixth Edition is the Molecular Cell Biology for a new generation, a dramatic revision of the classic text featuring two new co-authors, expanded coverage of immunology and development, and new media tools for students and instructors. NEW TO THIS EDITION * Increased clarity and accessibility, balancing coverage of the latest scientific developments with clear explanations of the fundamentals * New chapters: 'The Molecular Cell Biology of Development', 'Nerve Cells', and 'Immunology'. * Exciting new developments, including expanded coverage of proteomics, updated discussions of chromatin, evolution of chromosomes and the mitochondrion, molecular models, advances in light and electron microscopy, Reaction Oxygen Species (ROS), expanded coverage of RNAi, role of supercomplexes in electron transport, Human Epidermal Growth Factor Receptors (HERs), Myosin ATPase cycle, Kinesin 1 ATPase cycle, epithlial0to-mesenchymal transition and cancer, use of retrovirus infection for tracing cell lineage, axon guidance molecules, cancer stem cells, and use of DNA microarray analysis in tumor typing. The book is accompanied by a companion website (www.whfreeman.com/lodish6e), which supports learning and understanding through a wealth of supplementary material including online self-tests; animations and videos showing the dynamic nature of key cellular processes and important experimental techniques; and new podcasts narrated by the authors to give a deeper understanding of key figures in the text and a sense of the thrill of discovery.

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HARVEY LODISH is Professor of Biology and Professor of Bioengineering at the Massachusetts Institute of Technology, USA, and a member of the Whitehead Institute for Biomedical Research. Dr. Lodish is also a member of the National Academy of Sciences and the American Academy of Arts and Sciences and was President (2004) of the American Society for Cell Biology. He is well known for his work on cell membrane physiology, particularly the biosynthesis of many cell-surface proteins, and on the cloning and functional analysis of several cell-surface receptor proteins, such as the erythropoietin and TGF receptors. His laboratory also studies hematopoietic stem cells and has identified novel proteins that support their proliferation. Dr. Lodish teaches undergraduate and graduate courses in cell biology and biotechnology. ARNOLD BERK is Professor of Microbiology, Immunology and Molecular Genetics and a member of the Molecular Biology Institute at the University of California, Los Angeles, USA. Dr. Berk is also a fellow of the American Academy of Arts and Sciences. He is one of the original discoverers of RNA splicing and of mechanisms for gene control in viruses. His laboratory studies the molecular interactions that regulate transcription initiation in mammalian cells, focusing particular attention on transcription factors encoded by oncogenes and tumor suppressors. He teaches introductory courses in molecular biology and virology and an advanced course in cell biology of the nucleus. CHRIS A. KAISER is Professor and Head of the Department of Biology at the Massachusetts Institute of Technology, USA. His laboratory uses genetic and cell biological methods to understand the basic processes of how newly synthesized membrane and secretory proteins are folded and stored in the compartments of the secretory pathway. Dr. Kaiser is recognized as a top undergraduate educator at MIT, where he has taught genetics to undergraduates for many years. MONTY KRIEGER is the Whitehead Professor in the Department of Biology at the Massachusetts Institute of Technology, USA. For his innovative teaching of undergraduate biology and human physiology as well as graduate cell biology courses, he has received numerous awards. His laboratory has made contributions to our understanding of membrane trafficking through the Golgi apparatus and has cloned and characterized receptor proteins important for the movement of cholesterol into and out of cells, including the HDL receptor. MATTHEW P. SCOTT is Professor of Developmental Biology, Genetics and Bioengineering at Stanford University School of Medicine, USA, and Investigator at the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences and a past president of the Society for Developmental Biology. He is known for his work in developmental biology and genetics, particularly in areas of cell-cell signaling and homeobox genes and for discovering the roles of developmental regulators in cancer. Dr. Scott teaches development and disease mechanisms to medical students and developmental biology to graduate students at Stanford University. ANTHONY BRETSCHER is Professor of Cell Biology at Cornell University, USA. His laboratory is well known for identifying and characterizing new components of the actin cytoskeleton, and elucidating their biological functions in relation to cell polarity and membrane traffic. For this work, his laboratory exploits biochemical, genetic and cell biological approaches in two model systems, vertebrate epithelial cells and the budding yeast. Dr. Bretscher teaches cell biology to graduate students at Cornell University. HIDDE PLOEGH is Professor of Biology at MIT, USA, and a member of the Whitehead Institute for Biomedical Research. One of the world's leading researchers in immune system behaviour, Dr. Ploegh studies the various tactics that viruses employ to evade our immune responses, and the ways in which our immune system distinguishes friend from foe. Dr. Ploegh teaches immunology to undergraduate students at Harvard University and MIT. PAUL MATSUDAIRA is a member of the Whitehead Institute for Biomedical Research, Professor of Biology and Bioengineering at the Massachusetts Institute of Technology, USA, and Director of the WI/MIT BioImaging Center. His laboratory studies the mechanics and biochemistry of cell motility and adhesion and has developed high speed, high-through-put DNA analysis methods based on microfabricated chips.

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