Sickle Cell Disease (Oxford Medical Publications) - Hardcover
Sickle cell disease is one of the 'grand' diseases in the terminology of Victorian pathology, because its widespread and multitudinous manifestations may affect any organ system in the body. It has served as a model of molecular disease being one of the first genetic disorders to be explained
at the molecular level. Since publication of the Second Edition, however, further advances have been made. Much has been learnt about the causes of variability in the natural history of the disease and of the reasons why there are such marked variations in the patterns of morbidity and mortality.
As Director of The Jamaican Sickle Cell Unit, Graham Serjeant and his colleagues have shown the disease to be extremely variable ranging from a severe clinical course with death in early childhood to mildly affected patients living to the age of 80 years. This extreme variability within a single
genotype implies that other factors, both genetic and environmental, must influence expression of the disease. This new edition contains many new references and incorporates the latest thinking on the biology of the disease and the best practice in its management.
at the molecular level. Since publication of the Second Edition, however, further advances have been made. Much has been learnt about the causes of variability in the natural history of the disease and of the reasons why there are such marked variations in the patterns of morbidity and mortality.
As Director of The Jamaican Sickle Cell Unit, Graham Serjeant and his colleagues have shown the disease to be extremely variable ranging from a severe clinical course with death in early childhood to mildly affected patients living to the age of 80 years. This extreme variability within a single
genotype implies that other factors, both genetic and environmental, must influence expression of the disease. This new edition contains many new references and incorporates the latest thinking on the biology of the disease and the best practice in its management.
"synopsis" may belong to another edition of this title.
About the Author:
Graham R Serjeant , Director, Medical Research Council Laboratories (Jamaica), University of the West Indies, Kingston, Jamaica
Review:
" . . . this remains an excellent overview of sickle cell disease. It is well written and easy to read . . . I would consider this an excellent purchase for those with an interest in sickle cell disease." * ACP News *
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- PublisherOxford University Press
- Publication date2001
- ISBN 10 0192630369
- ISBN 13 9780192630360
- BindingHardcover
- Edition number3
- Number of pages792
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Sickle Cell Disease (Hardcover)
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Book Description Hardcover. Condition: new. Hardcover. Sickle cell disease was recognized to have a molecular basis more than 50 years ago, since when knowledge of the pathophysiology of the disease has paralleled the developments of molecular biology. Characterized by a striking red cell deformity, a great deal has been learnt about the mechanisms involved and animal models developed over the last 10 years have contributed to these studies. Despite greater understanding of the molecular mechanisms, this knowledge hashad little impact in improving management at the bedside. It is the authors' belief that much of importance remains to be learnt from clinical studies which ultimately may define the questions mostrelevant for our molecular colleagues to answer. Jamaica has provided a superb setting for clinical studies, which initially documented the extremely variable clinical course and then proceeded to seek the determinants in a Cohort Study based on newborn diagnosis and follow-up which has continued for the past 27 years. This new edition of Sickle Cell Disease reviews the history and many of the recent developments in laboratory studies but retains the perspective of a practisingclinician. A critical appraisal of the available observations and evidence has sought to define the best practice in its management. This new edition contains many new references and incorporates the latest thinking on the biology of the disease and the best practice in its management. Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Seller Inventory # 9780192630360
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Book Description Hardcover. Condition: new. Hardcover. Sickle cell disease was recognized to have a molecular basis more than 50 years ago, since when knowledge of the pathophysiology of the disease has paralleled the developments of molecular biology. Characterized by a striking red cell deformity, a great deal has been learnt about the mechanisms involved and animal models developed over the last 10 years have contributed to these studies. Despite greater understanding of the molecular mechanisms, this knowledge hashad little impact in improving management at the bedside. It is the authors' belief that much of importance remains to be learnt from clinical studies which ultimately may define the questions mostrelevant for our molecular colleagues to answer. Jamaica has provided a superb setting for clinical studies, which initially documented the extremely variable clinical course and then proceeded to seek the determinants in a Cohort Study based on newborn diagnosis and follow-up which has continued for the past 27 years. This new edition of Sickle Cell Disease reviews the history and many of the recent developments in laboratory studies but retains the perspective of a practisingclinician. A critical appraisal of the available observations and evidence has sought to define the best practice in its management. This new edition contains many new references and incorporates the latest thinking on the biology of the disease and the best practice in its management. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability. Seller Inventory # 9780192630360
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. This new edition contains many new references and incorporates the latest thinking on the biology of the disease and the best practice in its management. Seller Inventory # 594381926
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Book Description Hardcover. Condition: new. Hardcover. Sickle cell disease was recognized to have a molecular basis more than 50 years ago, since when knowledge of the pathophysiology of the disease has paralleled the developments of molecular biology. Characterized by a striking red cell deformity, a great deal has been learnt about the mechanisms involved and animal models developed over the last 10 years have contributed to these studies. Despite greater understanding of the molecular mechanisms, this knowledge hashad little impact in improving management at the bedside. It is the authors' belief that much of importance remains to be learnt from clinical studies which ultimately may define the questions mostrelevant for our molecular colleagues to answer. Jamaica has provided a superb setting for clinical studies, which initially documented the extremely variable clinical course and then proceeded to seek the determinants in a Cohort Study based on newborn diagnosis and follow-up which has continued for the past 27 years. This new edition of Sickle Cell Disease reviews the history and many of the recent developments in laboratory studies but retains the perspective of a practisingclinician. A critical appraisal of the available observations and evidence has sought to define the best practice in its management. This new edition contains many new references and incorporates the latest thinking on the biology of the disease and the best practice in its management. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Seller Inventory # 9780192630360
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Sickle Cell Disease (Oxford Medical Publications)
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ISBN 10: 0192630369
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