9780471418030

Organic Chemistry

Solomons, T. W. Graham; Fryhle, Craig B.

ISBN 10: 047141803X / 0-471-41803-X
ISBN 13: 9780471418030
Publisher: Wiley
Publication Date: 2001
Binding: Hardcover
Editorial Reviews:
Synopsis:
Includes a CD allowing readers to see animated mechanisms, examine three-dimensional structures and evaluate IR spectroscopy.
* Describes numerous and frequent biomedical applications.
* Balances coverage of functional groups organization with presentation of reaction mechanisms.
* Offers clear and thorough explanations of all concepts.

Review:
On the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest.


The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however.
A single 100-year-old tree provides only about one dose of the drug (roughly 300 mg). For this reason, as well as the spectacular molecular architecture of Taxol, synthetic organic chemists fiercely undertook efforts to synthesize it. Five total syntheses of Taxol have thus far been reported. Now, a combination of isolation of a related metabolite from European yew needles, and synthesis of Taxol from that intermediate, supply the clinical demand.

This case clearly demonstrates the importance of synthesis and the use of organic chemistry. It's just one of the many examples used in the text that will spark the interest of students and get them involved in the study of organic chemistry!

From the Back Cover

 

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Organic Chemistry (ISBN: 9780471418030)
Solomons, T. W. Graham;Fryhle, Craig B.
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