Gene Regulation : A Eukaryotic Perspective

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9780044452423: Gene Regulation : A Eukaryotic Perspective
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"Gene Regulation" provides a view of gene control systems from a eukaryotic standpoint, and tries to redress the bias towards prokaryotic control models. The text explores a variety of regulational strategies and defines their functional significance to the organism as a whole. The opening chapters examine the possible processes and mechanisms by which genes could be controlled at different levels, and establish that the key control structures lie at the level of gene transciption. Further chapters continue with an examination of the various steps in transcriptional regulation and explain how events at the molecular level finally have their impact on the biology of the organism via the expression of a diversity of proteins. The final section takes a look at the role of malregulation of gene expression in causing human diseases, particularly in relation to certain forms of cancer. This book should appeal to a wide range of intermediate and advanced students of molecular biology, biochemistry, genetics and clinicians working in these areas.

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About the Author:

David Latchman is Dean and Professor of Human Genetics at the Institute of Child Health, University College London.

Review:

Reviews from the first edition:; It is well written, lucid and makes easy reading. The illustrations are well thought out, plentiful, and easy to follow. There is an excellent reference list at the end of each chapter - Society for General Microbiology Quarterly; The text is lucid and free of jargon and generally a pleasure to read - The Lancet; Latchman has done a grand job of synthesis, and these chapters could form a useful background to more seasoned workers than undergraduates...Readers will be rewarded by an up-to-date, but very succinct, account of progress in an exciting and important area of modern biology - Times Higher Education Supplement; This is a timely and attractive short textbook that will be of considerable value to senior undergraduates, postgraduates, those entering the field for the first time, and their teachers. I shall be enthusiastically recommending it to my students; perhaps then they will understand my lectures and be able to answer the examination questions! - Applied Biodiversity and Biotechnology; This is an excellent student book. - Cellular and Molecular Biology; Rather than compiling a dry series of facts, an excellent pedagogue has threaded through the various chapters a logical scheme that allows smooth transitions from one regulatory mechanism to another and makes the reading actually quite enjoyable. Practical examples are judiciously chosen and introduced with extreme clarity...this book does a wonderful job of mentioning everyone's favourite hypotheses while placing them in a larger context and keeping alternative possibilities and interpretations wide open. Latchman's review should be highly recommended to motivated undergraduate and graduate students who want to immerse themselves in the facinating world of gene regulation - Trends in Genetics; The fast pace of research in this field makes the task of distilling it to under 300 pages a daunting one, but Latchman has succeeded admirably. The straighforward style of the text is complemented by clear, uncluttered diagrams, and the book will be welcomed by teachers as well as students in molecular biology and genetics - SGM Quarterly; I am glad to say that David Latchman, while updating his text for the second edition, has maintained all the appealing features of the first edition without any significant increase in length. The writing is clear, concise and authoritative. The simple line drawings are excellent. The contents focus on the principles of regualtion and are illustrated by well-chosen examples that do not overwhelm the reader with detail.... We certainly do live in exciting times and students and teachers will find that David Latchman captures them in this excellent book. - Biotechnology and Applied Biochemistry; This book serves as an important resource for any reader interested in the molecular basis of gene regulation. - Genetic Counselling; Reviews from the first edition:; The examples used to explain the variation in eukaryotic gene regulation are explained clearly and the diagrams [are] easy to understand ... This book may serve as a useful introduction to the field - Trends in Cell Biology; ...a great teaching aid - The Genetic Engineer and Biotechnologist.

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