Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity, Volume 47 (Current Topics in Membranes)

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9780120890309: Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity, Volume 47 (Current Topics in Membranes)

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.

Key Features
* Summarizes current state of amiloride-sensitive sodium channel field
* Analyzes structure-function of epithelial sodium channels
* Discusses immunolocalization of epithelial sodium channels
* Examines hormonal regulation of sodium channels
* Discusses sodium channels in lymphocytes, kidney, and lung
* Considers mechanosensitivity of sodium channels
* Provides ideas on sodium channels and disease

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From the Back Cover:

Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation, and their involvement in normal and pathophysiological situations. Edited by a recognized expert in the field with an international cadre of contributors, this work presents a timely update to current knowledge of amiloride-sensitive sodium channels.
* Analysis of structure-function relationships of epithelial sodium channels
* Immunolocalization of epithelial sodium channels
* Hormonal regulation of sodium channels
* Sodium channels in lymphocytes, kidney, and lung
* Mechanosensitivity of amiloride-sensitive sodium channels
* Sodium channels and disease

About the Author:

Douglas Fambrough, The John Hopkins University, Baltimore, Maryland, U.S.A.

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Published by Elsevier Science Publishing Co Inc, United States (1999)
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Book Description Elsevier Science Publishing Co Inc, United States, 1999. Paperback. Book Condition: New. 229 x 150 mm. Language: English . Brand New Book. Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations. Bookseller Inventory # AA59780120890309

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Published by Elsevier Science Publishing Co Inc, United States (1999)
ISBN 10: 0120890305 ISBN 13: 9780120890309
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Book Description Elsevier Science Publishing Co Inc, United States, 1999. Paperback. Book Condition: New. 229 x 150 mm. Language: English . Brand New Book. Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations. Bookseller Inventory # AA59780120890309

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