Analysis of Multifactorial Diseases (Human Molecular Genetics)

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9780121016104: Analysis of Multifactorial Diseases (Human Molecular Genetics)

A fast moving research area where there is an ever-expanding interest, and which impacts upon a wide variety of genetic diseases. Important introductory section which considers the merits of methods employed in these studies, and examines factors which influence study design. Looks at the different approaches that have been taken to study complex inherited diseases by considering a variety of common diseases as models. Discusses the successes achieved through past studies, with implications for future research.
Multifactorial or complex diseases are those characterized by increased risks within families, caused by more than one gene, and which predominantly have a tremendous impact on morbidity and mortality in the general public. Examples of multifactorial diseases include: common cancers - breast, bowel, ovary etc.: Alzheimer's; epilepsy; diabetes; multiple sclerosis; schizophrenia and manic depression; asthma; rheumatoid arthritis etc.

Key Features
* Introductory overview of genetic diseases and how they are identified
* Concluding summary chapter looking at approaches taken and lessons learnt - and their relatived impacts
* Section on methods of statistical analysis and design issues researchers should consider in their studies
* Chapters focus on specific diseases as model systems and examples, and look at the application of different methodologies to different diseases

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From the Back Cover:

Analysis of Multifactorial Disease describes the approaches taken to identify the genes that confer susceptibility to a range of 'complex' diseases, which do not follow standard Mendelian principles. The evidence for genetic factors in diseases such as rheumatoid arthritis, epilepsy, diabetes, Alzheimer's disease, asthma and ischemic heart disease is considered. Each chapter reviews both the successes and failures of current approaches, indicates where general conclusions can be drawn, and examines how multifactorial diseases can be studied more effectively in the future.
The book is not a manual of procedures, but a comprehensive review of the current state of the art. The work of both clinicians and researchers can be improved by understanding the approaches used to analyze other 'complex' diseases and, as such, Analysis of Multifactorial Disease is the most up-to-date reference source for researchers and clinicians alike.

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Book Description Academic Pr Inc, 2000. Taschenbuch. Book Condition: Neu. Neu new item; well packed; Neuware; Rechnung mit MwSt.; Bestellungen bis 15 Uhr werden am gleichen Werktag verschickt.Multifactorial diseases are genetic diseases influenced by more than one gene. As such, they are either inherited from parents or caused by mutation. Examples include common cancers, Alzeimer's, epilepsy, diabetes, multiple sclerosis, asthma, schizophrenia, manic depression, and rheumatoid arthritis. This title focuses on the studies used to analyze these diseases.; - Multifactorial diseases are genetic diseases influenced by more than one gene. As such, they are either inherited from parents or caused by mutation. Examples include common cancers, Alzeimer's, epilepsy, diabetes, multiple sclerosis, asthma, schizophrenia, manic depression, and rheumatoid arthritis. This title focuses on the studies used to analyze these diseases. 0 pp. Englisch. Bookseller Inventory # INF1000351466

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Book Description Elsevier Science Publishing Co Inc, United States, 2009. Paperback. Book Condition: New. 242 x 163 mm. Language: English . Brand New Book ***** Print on Demand *****. A fast moving research area where there is an ever-expanding interest, and which impacts upon a wide variety of genetic diseases. Important introductory section which considers the merits of methods employed in these studies, and examines factors which influence study design. Looks at the different approaches that have been taken to study complex inherited diseases by considering a variety of common diseases as models. Discusses the successes achieved through past studies, with implications for future research. Multifactorial or complex diseases are those characterized by increased risks within families, caused by more than one gene, and which predominantly have a tremendous impact on morbidity and mortality in the general public. Examples of multifactorial diseases include: common cancers - breast, bowel, ovary etc.: Alzheimer s; epilepsy; diabetes; multiple sclerosis; schizophrenia and manic depression; asthma; rheumatoid arthritis etc. Bookseller Inventory # AAV9780121016104

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Published by Elsevier Science Publishing Co Inc, United States (2009)
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Book Description Elsevier Science Publishing Co Inc, United States, 2009. Paperback. Book Condition: New. 242 x 163 mm. Language: English . Brand New Book ***** Print on Demand *****.A fast moving research area where there is an ever-expanding interest, and which impacts upon a wide variety of genetic diseases. Important introductory section which considers the merits of methods employed in these studies, and examines factors which influence study design. Looks at the different approaches that have been taken to study complex inherited diseases by considering a variety of common diseases as models. Discusses the successes achieved through past studies, with implications for future research. Multifactorial or complex diseases are those characterized by increased risks within families, caused by more than one gene, and which predominantly have a tremendous impact on morbidity and mortality in the general public. Examples of multifactorial diseases include: common cancers - breast, bowel, ovary etc.: Alzheimer s; epilepsy; diabetes; multiple sclerosis; schizophrenia and manic depression; asthma; rheumatoid arthritis etc. Bookseller Inventory # AAV9780121016104

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