Forensic DNA Typing, Second Edition: Biology, Technology, and Genetics of STR Markers

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9780121479527: Forensic DNA Typing, Second Edition: Biology, Technology, and Genetics of STR Markers

Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the "finished” reference sequence. The advent of modern DNA technology has resulted in the increased ability to perform human identity testing-desirable in a number of situations including the determination of perpetrators of violent crime such as murder and rape, resolving unestablished paternity, and identifying remains of missing persons or victims of mass disasters. The technology has been utilized in identifying remains from victims of the World Trade Center twin towers collapse following the terrorist attacks of September 11, 2001, the President Clinton-Monica Lewinsky scandal, and the identification of the remains in the Tomb of the Unknown Soldier. Indeed, our perceptions of history have been changed with DNA evidence that revealed Thomas Jefferson fathered a child by one of his slaves. This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century.

*The only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome
*Chapters cover the topic from introductory level right up to "cutting edge" research
*High-profile cases are addressed throughout the book, near the sections dealing with the science or issues behind these cases
*NEW TO THIS EDITION: D.N.A. Boxes--boxed "Data, Notes & Applications" sections throughout the book offer higher levels of detail on specific questions

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Book Description:

This enormously successful book gains ten new chapters on DNA typing sytems, mitochondrial DNA markers, Y chomosomes, and statistical analysis of short tandem repeat (STR) typing data --providing valuable insight on this fascinating new technology!

From the Back Cover:

Since it was first used in a criminal investigation in 1986, forensic DNA testing has become not only one of the most high profile tools available to the legal system, but also one with a very high degree of confidence. The use of DNA testing has helped determine the perpetrators of violent crimes, resolve questioned paternity and identify the remains of missing persons or victims of mass disasters.
John Butler has been involved, first in the validation of the short tandem repeat (STR) markers that form the basis of the FBI's nation-wide DNA database (CODIS) and, lately, in the development of new and innovative technologies that may influence the future of the field. If you are involved with forensic DNA testing in any way, you cannot afford not to own this book.
Short tandem repeat loci will be the most widely used markers in forensic DNA analysis for many years to come, and suitable information on STR typing is needed for crime laboratory personnel as well as members of the legal community. This book examines the science of current DNA typing methods by focussing on the biology and technology behind STR markers and the most common forensic DNA analysis methods used today.
Features:
* Chapters cover the topic from introductory level right up to "cutting edge" research
* Forensic scientists learn about the new methods and technologies required by STR typing
* DNA laboratories find out how to meet the training requirements of the DNA Advisory Board Quality Assurance Standards (listed in Appendix III).
* Lawyers and law enforcement professionals understand the science behind the techniques
* Information listed on suppliers of DNA analysis equipment, products and services

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John M. Butler
Published by Elsevier Academic Press (2005)
ISBN 10: 0121479528 ISBN 13: 9780121479527
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John M. Butler Ph.D. (Analytical Chemistry) University of Virginia
Published by Academic Press (2005)
ISBN 10: 0121479528 ISBN 13: 9780121479527
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