Adenoviral Vectors for Gene Therapy

ISBN 13: 9780121995041

Adenoviral Vectors for Gene Therapy

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9780121995041: Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.

Key Features
* Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors
* Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement
* Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
* Discusses utility of adenoviral vectors in animal disease models
* Considers Federal Drug Administration regulations for human clinical trials

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From the Back Cover:

Adenoviral Vectors for Gene Therapy provides detailed, comprehensive coverage of the gene delivery vehicles, based on the adenovirus, emerging as important tools in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. The broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.

Key Features
* Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors
* Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement
* Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
* Discusses utility of adenoviral vectors in animal disease models
* Considers Federal Drug Administration regulations for human clinical trials

About the Author:

David T. Curiel, M.D., Ph.D. is the Director of the Cancer Biology Division of the Department of Radiation Oncology at Washington University School of Medicine. Dr. Curiel graduated medical school at Emory University in 1982, where he also completed his internship and residency in Internal Medicine. Dr. Curiel's scientific training includes tenureship at the National Institutes of Health in Bethesda, Maryland at the Pulmonary Branch of the Heart and Lung, and Blood Institute (NHLBI) from 1985-1989, and a fellowship in Biotechnology at the National Cancer Institute, Navy Medical Oncology Branch from 1989-1990. He received his Ph.D. from University of Groningen in The Netherlands in 2002. Dr. Curiel has been at Washington University School of Medicine since 2011. In addition to his role as Director of the Cancer Biology Division, he is Director of the Biologic Therapeutics Center.

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Book Description Academic Press, 2002. Book Condition: New. Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: Adenovirus Structure Biology of Adenovirus Cell Entry Adenovirus Replication Adenoviral Vector Construction I: Mammalian Systems Adenoviral Vector Construction II: Bacterial Systems Propagation of Adenoviral Vectors: Use of PER.C6 Cells Purification of Adenovirus Targeted Adenoviral Vectors I: Transductional Targeting Targeted Adenoviral Vectors II: Transcriptional Targeting Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer Innate Immune Responses to in Vivo Adenovirus Infection Humoral Immune Response Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications Xenogenic Adenoviral Vectors Hybrid Adenoviral Vectors Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations Imaging Adenovirus-Medicated Gene Transfer. Bookseller Inventory # ABE_book_new_0121995046

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