Tissue-Specific Toxicity: Biochemical Mechanisms

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9780122088605: Tissue-Specific Toxicity: Biochemical Mechanisms

This volume provides an up-to-date review of the molecular mechanisms of toxicity. Individual chapters deal with specific aspects of toxicity problems associated with selected organs.

  • Contains a review of contemporary knowledge of the molecular mechanisms of toxicity as applied to various organs
  • Contrasts with other volumes in dealing with the mechanistic approach to the subject
  • Discusses selected organs in separate chapters

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Tissue-specific toxicity can involve target-organ-specific metabolism, accumulation of xenobiotics, and tartet-organ-specific responses to insults.
In recent years, there has been a tendency to specialise in certain areas, such as liver enzyme bioactivation. This volume brings together contributions reviewing widely differing fields of toxicology centering around the problem of tissue-specific toxicity. It should help counter overspecialisation and bring into perspective research needs in the rapidly developing science of toxicology.

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"It is a fitting tribute to a man who spent much of his research career establishing the role of chemical specificity in toxicity." --ATLA

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