Given the fast pace of discover in this filed, Molecular Genetics of Cancer provides a welcome authoritative review of key genes known to be critical in the development or progression of human cancer. Written by experts from North America and Europe, the subjects covered include: the function of genes predisposing to retinoblastoma, Wilms' tumour and neurofibromatosis, and the cloning of genes recently identified as being associated with breast cancer, multiple endocrine neoplasia, colon cancer and rhabdomyosarcoma. One chapter is devoted entirely to p53, perhaps the most frequently mutated gene in all human cancers. The potential use of transgenic mice with loss of cancer gene function is also explored.
This volume in the Human Molecular Genetics series is essential reading for all researchers studying the genetics of cancer. Throughout the book, scientific advances and their clinical relevance are covered in detail, particularly in the light of findings concerning the inheritance of genes predisposing to tumorigenesis. This book is therefore also a valuable reference source for clinicians and genetic counselors.
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John K. Cowell, Haematology and Oncology Unit, Institute of Child Health, London, UK
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Book Description Academic Press, 1995. Hardcover. Book Condition: Very Good. Bookseller Inventory # mon0000420188