The Adhesion Molecule FactsBook, Second Edition

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9780123565051: The Adhesion Molecule FactsBook, Second Edition

This updated and expanded Second Edition of The Adhesion Molecule FactsBook has nearly double the number of entries of the First Edition, and provides a compendium of the major cell surface adhesion molecules.
The introductory chapters detail the organization of the data in the entries section, provide a background to the main adhesion molecule families, and inform the reader how to access information on adhesion molecules on the Internet.
The entries have been designed to allow the reader to quickly establish the main structure and functional features of each molecule and where to find information.

  • alternative nomenclature
  • tissue distribution and regulation of expression
  • ligands
  • gene organization and chromosomal location
  • protein structure and molecular weights
  • amino acid sequence of the most commonly studied organisms
  • PIR, SWISSPROT, and EMBL/GenBank accession numbers
  • biological function
  • key references

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From the Back Cover:

How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers, and databases to locate that elusive fact?

The Academic Press FactsBook series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "A growing series of excellent manuals" by Molecular Medicine Today and "Essential works of reference" by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources. Using an easy-to-follow format, the new second editions will now keep you up-to-date with the latest advances, and provide you with all the new facts at your fingertips. Meticulously researched and compiled by experts in the field, keeping abreast of developments has never been so easy!

The Second Edition of The Adhesion Molecule FactsBook has been completely revised, updated, and expanded to reflect the advances made in the field since publication of the first edition. It contains over 80 entries (nearly twice the number of the previous edition) on all currently cloned and characterized cell adhesion molecules, including the families of

  • integrins
  • cadherins
  • selectins
  • members of the immunoglobulin superfamily
  • syndecans
  • and other relevant receptors

Provides information on:

  • protein structure and molecular weights
  • amino acid sequence of the most commonly studied organisms
  • gene organization and chromosomal location
  • alternative nomenclature
  • ligands
  • biological function
  • tissue distribution
  • disease association
  • knockout mice
  • database accession numbers
  • key references

About the Author:

Clare Isacke received her undergraduate degree in biochemistry in Oxford, her D.Phil. in Oxford working with John Heath and Chris Graham on growth control and differentiation of embryonal carcinoma cells. She worked as a postdoctoral fellow at the Salk Institute in La Jolla, California, with Tony Hunter and Ian Trowbridge on cell adhesion and tyrosine kinase receptors. She has been at Imperial College now for 10 years during which time the lab has been focussing on cell adhesion receptor. Isacke did a three-year stint in the Biochemistry Department at Imperial College setting up her own lab within the Colin Hopkins empire and then moved over to the Biology Department taking up a University-funded post.

Michael Horton trained in Biochemistry, Medicine and Haematology at St. Bartholomew's Hospital Medical College, London before research training in Immunology at University College, London. He has held senior appointments at St. Bartholomew's Hospital and with the Imperial Cancer Research Fund. He is currently Professor of Medicine and Head of the Bone and Mineral Center, University College, London. His research interests focus on the cell and molecular biology of bone, with a special interest in cell adhesion receptors, and in the development of novel therapeutics for bone disease.

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