Principles of Clinical Pharmacology, Second Edition

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9780123694171: Principles of Clinical Pharmacology, Second Edition

This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists.

* Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy.
* Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course.
* Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study.
* Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry.
* Expanded coverage of pharmacogenetics
* Expanded coverage of drug transporters and their role in interactions
* Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions
* A new chapter on drug discovery that focuses on oncologic agents
* Inclusion of therapeutic antibodies in chapter on biotechnology products

"synopsis" may belong to another edition of this title.

From the Back Cover:

The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. For this reason, this book focuses on the principles that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles that is presented in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents.

New to the Second Edition

The Second Edition retains the goal, format, and presentation style of the first edition but has been extensively updated and revised with the inclusion of many new authors and co-authors. In addition the second edition features:

* Pharmacogenetics - Expanded coverage of pharmacogenetics.

* Expanded coverage of drug transporters and their role in interactions.

* New material added on enzyme induction mechanisms to the chapters on drug metabolism and drug interactions.

* New Chapter! – A new chapter on Drug Discovery has been added with a focus on oncologic agents.

* New coverage of therapeutic antibodies has been added to the chapter on biotechnology products.

Hallmark Features

* Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy.

* Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course.

* Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study.

* Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry.

About the Author:

Arthur Atkinson, NIH Clinical Center, Bethesda, Maryland, U.S.A.
Charles Daniels, NIH Clinical Center, Bethesda, Maryland, U.S.A.
Robert Dedrick, NIH Clinical Center, Bethesda, Maryland, U.S.A.
Charles Grudzinskas, Center for Drug Development Science at Georgetown University, U.S.A.
Sanford P. Markey, National Institute of Mental Health and NIH Clinical Center, Bethesda, Maryland, U.S.A.

"About this title" may belong to another edition of this title.

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