Nitric Oxide: Biology and Pathobiology

ISBN 13: 9780123738660

Nitric Oxide: Biology and Pathobiology

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9780123738660: Nitric Oxide: Biology and Pathobiology
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Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide’s role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology.

  • Edited by Nobel Laureate Louis J. Ignarro
  • Up-to-date therapeutic implications of nitric oxide research
  • Authored by world experts on nitric oxide
  • Detailed research of the biochemistry and synthesis of nitric oxide

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About the Author:

Louis J. Ignarro, PhD, is Distinguished Professor Emeritus of the Department of Molecular and Medical Pharmacology at the UCLA School of Medicine. He has broad and extensive experience in the molecular and chemical biology of the nitric oxide-cyclic GMP signaling systems. He and his basic research teams have discovered and expanded the production and actions of nitric oxide in mammalian tissues, including the protective roles of nitric oxide in preventing hypertension, stroke and myocardial infarction, and its neurotransmitter role as the mediator of erectile function in humans. For these discoveries, he was awarded the Nobel Prize in Physiology or Medicine.

Review:

"... for those researchers interested in the detailed biochemistry of nitric oxide and its synthesis, the book will be a very valuable reference" - Today's Life Sciences --Review

"... for those researchers interested in the detailed biochemistry of nitric oxide and its synthesis, the book will be a very valuable reference"
--TODAY'S LIFE SCIENCE
"Louis J. Ignarro, pharmacologist in Los Angeles, participated in the quest for EDRF's chemical nature. He performed a brilliant series of analyses and concluded in 1986, together with and independently of Robert Furchgott, that EDRF was identical to NO. The problem was solved and Furchgott's endothelial factor identified. When Furchgott and Ignarro presented their conclusions at a conference in July 1986, it elicited an avalanche of research activities in many different laboratories around the world. This was the first discovery that a gas can act as a signal molecule in an organism."
--THE NOBEL ASSEMBLY, KAROLINSKA INSTITUTE, 1998

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