The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.
Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality.
Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.
"synopsis" may belong to another edition of this title.
"Reviewing the current advances in the progression and therapeutic approaches to bone cancer is an extremely challenging task. Bone cancer is not a single disease; rather, it is a field comprising a diverse and complex range of malignancies, from primary bone tumors of stromal cell origin, to hematopoietic malignancies and secondary metastatic bone disease. Dominique Heymann has assembled an exciting, comprehensive and up-to-date series of reviews contributed by experts in the basic and clinical aspects of bone research. In the past decade, our understanding of cancers involving bone has increased tremendously, underpinned by advances in the cellular, molecular and biochemical mechanisms of bone cell interactions in health and disease, together with advances in genetics, diagnostics, imaging and therapeutic strategies. All these aspects are covered in this timely volume, which will galvanize further cooperative efforts in the coming years between basic researchers, oncologists and pathologists towards understanding the causes of different bone cancers and translating this knowledge into the clinic."
-- Agi E. Grigoriadis, PhD, Departments of Craniofacial Development and Orthodontics, King's College London, United Kingdom
"Our understanding of bone biology and diseases has strikingly progressed in the last decade. In parallel, the processes that lead to various forms of cancer have been further unraveled and the mechanisms leading to metastatic spread further explored. In this book, Dr. Heymann has gathered some of the world experts on these subjects to explore the cutting edge where these fields merge in the context of bone cancer and metastasis, their pathophysiology, diagnosis and treatment. This encompassing book will undoubtedly meet the needs of residents and fellows as well as expert clinicians and scientists."
--Roland Baron, Professor, Harvard Medical School, Boston MA, USAAbout the Author:
Dominique Heymann studied cell biology, biochemistry and immunology in INSERM (French NIH) unit 211 at the University of Nantes and received his Ph.D. in 1995. He was appointed Associate Professor in 2001 in the Department of Histology and Embryology. In 2009, he was awarded a personal Chair of Histology and Embryology.
Currently he is the Quality Control Manager of the Tissue Bank and Gene and Cellular Therapy Unit at Nantes Hospital. He heads a laboratory research group (INSERM UMR 957) of 65 people at the Faculty of Medicine, where the pathogenesis of primary bone tumours, and more specifically, the role of bone microenvironment (osteoclasts, mesenchymal stem cells, OPG/RANK/RANKL, IL-6 and MCSF cytokine family) in tumour growth is studied.
In 2006, Dominique Heymann won the Paul Mathieu prize from the National Academy of Medicine for his work entitled "From the osteolytic process associated to primary bone tumors to the development of bi-therapies for osteosarcoma”. He was on the national scientific advisory board of INSERM (2008-2012) and is now Co-Chairman of INSERM scientific commission n°5 ("Physiology and pathophysiology of endocrine, bone, skin and gastrointestinal tissues”). He has authored approximately 180 publications in peer- reviewed journals, more than 300 abstracts and 20 book chapters. He is also Associate Editor of Life Sciences, Academic Editor of PLoS ONE, Editor-in-Chief of the Open Bone Journal and serves on the Editorial Board of Current Medicine Chemistry, European Journal of Pharmacology, and Journal of Bone Oncology.
"About this title" may belong to another edition of this title.
Book Description Hardcover. Book Condition: New. Bookseller Inventory # 001476
Book Description Academic Press, USA, 2009. Hardcover. Book Condition: Neu. 1. Auflage. Bookseller Inventory # 000025
Book Description Book Condition: New. Dust Jacket Condition: New. Shipped promptly and delivered within 3 to 5 working days. For PO BOX, APO, FPO and Puerto Rico addresses delivery done in 20 to 25 working days. Serving customers since 2006. Thousand of satisfied customers!. Bookseller Inventory # MISC_9780123748959_Elsev1012_18
Book Description Book Condition: New. Brand New Book In Mint Condition. Shipping With Trackable Method. No APO/FPO Addresses Please. Bookseller Inventory # 9780123748959NHS
Book Description Book Condition: Brand New. Brand New Original US Edition, Perfect Condition. Printed in English. Excellent Quality, Service and customer satisfaction guaranteed!. Bookseller Inventory # AIND-96194
Book Description Book Condition: New. New. US edition. Perfect condition. Ship by express service to USA, Canada, Australia, France, Italy, UK, Germany and Netherland. Customer satisfaction our priority. Bookseller Inventory # ABE-FEB-15512
Book Description Book Condition: Brand New. New. US edition. Customer Satisfaction guaranteed!!. Bookseller Inventory # SHUB15512
Book Description Book Condition: New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery. Bookseller Inventory # AUSBNEW-96194
Book Description Book Condition: Brand New. New, US edition. Excellent Customer Service. Bookseller Inventory # ABEUSA-15512
Book Description Book Condition: New. New. US edition. Perfect condition. Ship by express service to USA, Canada, Australia, France, Italy, UK, Germany and Netherland. Customer satisfaction our priority. Bookseller Inventory # ABE-FEB-15513