Proteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search. Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area.
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Recent efforts have provided dramatic increases in our understanding of the structure and function of proteolytic enzymes of infectious agents. As the activity of proteases is in many cases essential to the life cycle of the infectious organism, the development of selective and potent inhibitors may lead to new therapeutic agents. Proteases of Infectious Agents collects reviews from leading experts describing the latest information of the properties of key enzymes from a variety of fungi, viruses, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area.
* Clearly explains the background biology and function of proteases
* Discusses the role of proteases as important new targets for drug discovery
* Provides a complete picture of protease structure through genomic analysis and crystallography
* Presents a global survey of research to date in protease inhibitors, featuring cutting-edge technology
* Discusses major diseases that provide economically important targets
* Illustrates how structure-based drug design saves time by targeting effective and selective compounds
* Includes high-quality color illustrations that reinforce and clarify points discussed
Ben M. Dunn, Ph.D., is a Distringuished Professor of Biochemistry and Molecular Biology at the University of Florida, Gainesville.
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Book Description Academic Press, 1999. Paperback. Book Condition: Brand New. 324 pages. 9.00x6.00x0.77 inches. In Stock. Bookseller Inventory # zk0123886600