DNA Methylation and Complex Human Disease (Translational Epigenetics)

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9780124201941: DNA Methylation and Complex Human Disease (Translational Epigenetics)
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DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies.

This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease.

Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis.

  • Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity
  • Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field
  • Describes wholly new concepts, including the linking of metabolic pathways with epigenetics
  • Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

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In DNA Methylation in Complex Human Disease, expert authors review the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including therapies and the possibility of using methyl donors. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis. The authors also present the importance of high-throughput methylome analysis, as well as the advantages of DNA methylation as a biomarker over other molecular processes. DNA Methylation in Complex Human Disease is an excellent resource for basic biology and translational researchers interested in developmental biology, genetics health genomics, epigenesist in complex disease, and therapeutic possibilities, and developmental biologists, geneticists, biotechnologists, and epidemiologists have much to gain from this specialized and focused volume.

About the Author:

Professor Neidhart is a senior scientist at the Center of Experimental Rheumatology, Centre for Clinical Research, Switzerland.

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Book Description Elsevier Science Publishing Co Inc, United States, 2015. Hardback. Condition: New. Language: English . Brand New Book. DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Seller Inventory # AA59780124201941

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Book Description Elsevier Science Publishing Co Inc, United States, 2015. Hardback. Condition: New. Language: English. Brand new Book. DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Seller Inventory # AA59780124201941

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Book Description Oxford Elsevier LTD Dez 2015, 2015. Buch. Condition: Neu. Neuware - DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. . This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. Indeed both demethylating agents are currently used in clinical practice for myelodysplastic syndrome and cutaneous T cell lymphoma. However, the situation might be completely different in non-neoplastic disease, where it could be beneficial to reverse DNA demethylation, for example in autoimmune diseases. Thus, the possibility to use methyl donors will be discussed. . In the concluding part of the book, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases, such as rheumatoid arthritis. 529 pp. Englisch. Seller Inventory # 9780124201941

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Book Description Oxford Elsevier LTD Dez 2015, 2015. Buch. Condition: Neu. Neuware - DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. . This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. Indeed both demethylating agents are currently used in clinical practice for myelodysplastic syndrome and cutaneous T cell lymphoma. However, the situation might be completely different in non-neoplastic disease, where it could be beneficial to reverse DNA demethylation, for example in autoimmune diseases. Thus, the possibility to use methyl donors will be discussed. . In the concluding part of the book, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases, such as rheumatoid arthritis. 529 pp. Englisch. Seller Inventory # 9780124201941

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Book Description Oxford Elsevier LTD Dez 2015, 2015. Buch. Condition: Neu. Neuware - DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. . This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. Indeed both demethylating agents are currently used in clinical practice for myelodysplastic syndrome and cutaneous T cell lymphoma. However, the situation might be completely different in non-neoplastic disease, where it could be beneficial to reverse DNA demethylation, for example in autoimmune diseases. Thus, the possibility to use methyl donors will be discussed. . In the concluding part of the book, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases, such as rheumatoid arthritis. 529 pp. Englisch. Seller Inventory # 9780124201941

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