Eukaryotic Transcription Factors

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9780124371729: Eukaryotic Transcription Factors

The revised edition of this book provides an up-to-date overview of the role of transcription factors in gene regulation, focusing primarily on the role of individual specific factors in biological processes such as the steroid response, and cell-type determination. Transcription factors play a fundamental role in turning genes on and off in particular cell types, during embryonic development, or in response to specific skills and are of interest to scientists from a variety of disciplines. However, the bewildering array of these proteins and the different ways in which they act can prove daunting to scientists and newcomers to molecular genetics. This book aims to provide the reader with a clear understanding of this field. It should be useful reading for those who seriously wish to understand the impact of molecular biology on medicine, whatever their speciality.

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From the Publisher:

Praise for Previous Editions "A standard for the genre...presented with great clarity...profusely illustrated...admirably up-to-date." ( The Lancet)

From the Back Cover:

Familiarity with the mechanisms of eukaryotic gene regulation is now essential for scientists and students in both clinical and basic disciplines. However, the vast array of transcription factors, which are central to such regulation, can prove daunting to students and newcomers to this fascinating field of molecular genetics. The Third Edition of Eukaryotic Transcription Factors provides the reader with a clear and concise understanding of transcription factors, but also of their vital role in the regulation of transcription in different cell types during development and in disease.
Revised and completely up-to-date, the Third Edition of Eukaryotic Transcription Factors has been extensively rewritten to reflect the rapid advances in the field. These include the emerging roles of specific co-activator molecules such as CBP in the action of a number of different transcription factors emphasizing particularly their ability to modulate chromatin structure. New sections cover current methods for determining DNA binding specificity, regulation by protein degradation and processing, Pax family transcription factors, and novel anti-oncogenic transcription factors, as well as a discussion of transcription factors in human diseases. A special new colour section illustrates the various aspects of transcription factor structure.
Emphasising common motifs, themes and mechanisms this volume covers:
* Major families of eukaryotic transcription factors
* Mechanisms of gene activation and repression
* Structure-function relationships
* Their roles in inducible and cell type-specific gene expression, development, differentiation, and human diseases including cancer
* Methods of study in vivo and in vitro
Essential reading for all those who seriously wish to understand the impact of molecular biology on medicine, whatever their specialty.

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Latchman, David S.
Published by Academic Pr (1995)
ISBN 10: 0124371728 ISBN 13: 9780124371729
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David S. Latchman
Published by Academic Pr (1995)
ISBN 10: 0124371728 ISBN 13: 9780124371729
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