Complement: Clinical Aspects and Relevance to Disease

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9780125069557: Complement: Clinical Aspects and Relevance to Disease

The apparent complexity of the complement system strikes fear into many medical students and clinicians. For them and those involved in complement research, this book provides a clear and concise explanation of the biochemistry, genetics and biological activity of the complement pathway, using diagrams wherever possible to aid understanding of this fascinating arm of the immune response.
From this basis, the important role of the complement system in the normal immune response and a variety of clinical disorders including rheumatoid, renal, neurological and dermatological disease are detailed.
Using his experience as a senior clinical research fellow at the University of Wales College of Medicine, Dr. Morgan amply addresses the science of complement system to a medically trained audience and vice versa.

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"Complement: Clinical Aspects and Relevance to Disease is an excellent guide to the complement system for both physicians and basic scientists... One of the primary strengths of Paul Morgan's book is its comprehensive listing of biological functions and diseases in which complement is considered to play an important role... The photographs, illustrations and tables are outstanding... In comparison with its predecessors, this book is more comprehensive in its inclusion of diseases in which complement activation may be a factor... In summary, Complement: Clinical Aspects and Relevance to Disease is recommended reading for anyone who wants to learn more about the complement system, either as an introduction for basic research or as a guide to understanding the role of complement in disease."
--IMMUNOLOGY TODAY
"Even the most dedicated complementologist is hard pressed to keep abreast of all recently published work, so it is hardly surprising that general immunologists, clinicians, and students find the subject forbidding. More information, if poorly organised, can lead to less understanding; the lack of a concise account of the complement system and of its role in disease has been a major disadvantage. Morgan's excellent book admirably fills this particular niche. It provides a clear account of the biochemistry of the activation mechanisms and the biological activities which are generated as a result of complement activation."
--LANCET

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