Signal transduction is one of the most rapidly expanding fields in biomedical research. Written by renowned experts, Intracellular Signal Transduction provides up-to-date reviews on the role of protein phosphorylation cascades, and the structure, regulation, and function of protein kinases and phosphatases. This volume was compiled in honor of Dr. Edwin Krebs' pioneering work in the field of signal transduction which earned him a Nobel Prize. It provides information in a variety of areas relating to the biochemistry, cell biology, and pharmacology of the signal transduction process in eukaryotic cells.
Key Features
* Contains current reviews in signal transduction processes in eukaryotic cells
* Presents the structure and function of protein kinases and phosphatases
* Highlights MAP kinase cascades, tyrosine phophatases, pharmacology of protein kinases, and cyclic nucleotide phosphodiesterases
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Angus C. Nairn is currently Associate Professor at The Rockefeller University. He has published a large number of papers concerned with the structure and regulation of protein kinases and phosphatases involved in signal transduction, particularly with respect to signalling by calcium.
Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.
Praise for the Serial
"Recommended not only to pharmacologists but also to all those in related disciplines."
--NATURE
"Superb reading material."
--JOURNAL OF PHARMACEUTICAL SCIENCES
"The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated."
--H.E. Kaufmann in CHEMOTHERAPY
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