For students as well as researchers this book describes the exciting new advances in the molecular biology of transport proteins and integrates this information with transport kinetics, function, and regulation. Experimental data are linked with theory.
* Provides an introduction to the properties of transport proteins: channels, carriers, and pumps
* Presents up-to-date information on the structure of transport proteins and on their function and regulation
* Includes introductions to transport kinetics and to the cloning of genes that code transport proteins
* Furnishes a link between the experimental basis of the subject and theoretical model building.
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Wilfred Stein is the author of three previous books on membrane transport, the first appearing almost fifty years ago. He has edited numerous books and written some 180 papers on various aspects of membrane transport and especially transport kinetics. These papers, especially those written together with his colleague William Lieb, defined many of the concepts used today in discussing movement across cell membranes. More recently he has turned to the study of the kinetics of drugs used in cancer therapy and in the treatment of malaria. He has taught biochemistry, biophysics and physiology at the University of Manchester and the Hebrew University of Jerusalem and also at the Weizmann Institute in Israel. He is currently Emeritus Professor of Biophysics at the Hebrew University. He is married to a librarian and has four children and nine grandchildren.
Thomas Litman works as a senior research scientist at LEO Pharma, where he is responsible for implementing bioinformatics in translational research. He has taught biophysics and transport physiology at the University of Copenhagen since 1994 and is the author of some 70 papers, most of which focus on multidrug resistance and functional characterization of drug transporters, such as P-glycoprotein. In particular the papers on transport kinetics of anticancer drugs, written together with his mentor, Professor Wilfred Stein, have been recognized as exemplary in the field. He completed his post-doctoral work at The National Cancer Institute, NIH 1997-9, where he played a key role in the identification and characterization of a new transporter, ABCG2 (MXR), involved in multidrug resistance. In 2002 he was appointed as Weimann associate research professor, and 2003-6 he was responsible for the master's program in medical bioinformatics at the Bioinformatics Centre, University of Copenhagen. His interests range from basic and translational research to information technology and applied bioinformatics, including confocal microscopy, microarray analysis, noncoding RNA, proteomics, next-generation sequencing, and molecular modeling.
A book that provides a solid foundation for those entering the field at the research level, as well as for more advanced students, is timely. This book fulfils such a role admirably. Even though it addresses a rapidly moving field, this book is not simply a progress report but is complete in itself. It provides, in a clear and comprehensive fashion, the background and framework essential for putting into perspective a rapidly expanding body of information on the molecular basis of channels, carriers, and pumps.
One of the most attractive and important aspects of the book is that it places kinetic and regulatory studies, which often seem boring, irrelevant or incomprehensible, into context, making them readily accessible and emphasizing their importance. It is unusual, at least in my experience, to find a book or article addressing 'pre-molecular biology' aspects of research that is both enjoyable to read and so admirably places such research in the context of current molecular thinking.
I strongly recommend this book to anyone interested in, or needing to gain an understanding of, the basis of membrane transport.
With so much diversity in biology it is exhilarating to read Stein's attempt at synthesis. More of this is needed.
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Book Description Academic Press. Hardcover. Book Condition: New. 0126650454 New Condition. Bookseller Inventory # NEW6.1037644
Book Description Academic Press, 1990. Hardcover. Book Condition: New. Bookseller Inventory # P110126650454
Book Description Academic Press, 1990. Hardcover. Book Condition: New. Bookseller Inventory # DADAX0126650454