The Practice of Medicinal Chemistry, Second Edition

4 avg rating
( 5 ratings by GoodReads )
9780127444819: The Practice of Medicinal Chemistry, Second Edition

The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process.

* The only book available dealing with the practical aspects of medicinal chemistry
* Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production
* Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry

"synopsis" may belong to another edition of this title.

Book Description:

A complete guide to the drug discovery process for medicinal chemists.

About the Author:

Camille-Georges Wermuth PhD, Prof. and Founder of Prestwick Chemical, was Professor of Organic Chemistry and Medicinal Chemistry at the Faculty of Pharmacy, Louis Pasteur University, Strasbourg, France from 1969 to 2002. He became interested in Medicinal Chemistry during his two years of military service in the French Navy at the "Centre d'Etudes Physio-biologiques Appliquées à la Marine" in Toulon. During this time he worked under the supervision of Dr Henri Laborit, the scientist who invented artificial hibernation and discovered chlorpromazine.

Professor Wermuths' main research themes focus on the chemistry and the pharmacology of pyridazine derivatives. The 3-aminopyridazine pharmacophore, in particular, allowed him to accede to an impressive variety of biological activities, including antidepressant and anticonvulsant molecules; inhibitors of enzymes such as mono-amine-oxidases, phosphodiesterases and acetylcholinesterase; ligands for neuro-receptors: GABA-A receptor antagonists, serotonine 5-HT3 receptor antagonists, dopaminergic and muscarinic agonists. More recently, in collaboration with the scientists of the Sanofi Company, he developed potent antagonists of the 41 amino-acid neuropeptide CRF (corticotrophin-releasing factor) which regulates the release of ACTH and thus the synthesis of corticoids in the adrenal glands. Professor Wermuth has also, in collaboration with Professor Jean-Charles Schwartz and Doctor Pierre Sokoloff (INSERM, Paris), developed selective ligands of the newly discovered dopamine D3 receptor. After a three-year exploratory phase, this research has led to nanomolar partial agonists which may prove useful in the treatment of the cocaine-withdrawal syndrome.

Dr. Wermuth is co-author or editor of several books, the author of over 250 scientific papers and holds nearly 60 patents. Professor Wermuth is also the recipient of the Charles Mentzer Prize of the Société Française de Chimie Thérapeutique, the Léon Velluz Prize of the French Academy of Science, the Prix de l'Ordre des Pharmaciens by the French Academy of Pharmacy and the Nauta Award of the European Federation for Medicinal Chemistry for Pharmacochemistry in 2010.

"About this title" may belong to another edition of this title.

Buy New View Book
List Price: US$ 260.00
US$ 54.80

Convert Currency

Shipping: US$ 7.39
From United Kingdom to U.S.A.

Destination, Rates & Speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

ISBN 10: 0127444815 ISBN 13: 9780127444819
New Quantity Available: 1
Seller
Phatpocket Limited
(Waltham Abbey, HERTS, United Kingdom)
Rating
[?]

Book Description Book Condition: New. New. Book is new and unread but may have minor shelf wear. Bookseller Inventory # Z1-L-009-00393

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 54.80
Convert Currency

Add to Basket

Shipping: US$ 7.39
From United Kingdom to U.S.A.
Destination, Rates & Speeds

2.

Published by Academic Press (2003)
ISBN 10: 0127444815 ISBN 13: 9780127444819
New Hardcover Quantity Available: 1
Seller
Book Deals
(Lewiston, NY, U.S.A.)
Rating
[?]

Book Description Academic Press, 2003. Book Condition: New. Brand New, Unread Copy in Perfect Condition. A+ Customer Service! Summary: Foreward. Preface. A Brief History Of Drugs From Plant Extracts To DNA Technology Medicinal Chemistry: Definition And Objectives, The Three Main Phases Of Drug Activity, Drug And Diseases Classifications Measurement And Expression Of Drug Effects Drug Targets: Molecular Mechanisms Of Drug Action Strategies In The Search For New Lead Compounds Or Original Working Hypotheses Natural Products As Pharmaceuticals And Sources For Lead Structures Basics Of Combinatorial Chemistry The Contribution Of Molecular Biology To Drug Discovery Electronic Screening: Lead Finding From Database Mining High-Speed Chemistry Libraries: Assessment Of Drug-Likeness Web Alert Using The Internet For Medicinal Chemistry Molecular Variations In Homologous Series: Vinylogues And Benzologues Molecular Variations Based On Isosteric Replacements Ring Transformations Introduction Of Conformational Restriction And/Or Steric Hindrance Identical And Non Identical Twin Drugs Optical Isomerism In Drugs Application Strategies For The Primary Structure-Activity Relationship Exploration Specific Substituent Groups The Role Of Functional Groups In Drug-Receptor Interactions Compound Properties And Drug Quality Quantitative Approaches To Structure-Activity Relationships Structural Aspects Of Drug Action I Pharmacophore Identification And Receptor Mapping Three-Dimentional Quantitative Structure-Property Relationships Protein Crystallography And Drug Discovery Protein Comparative Modelling And Drug Discovery The Transition From Agonist To Antagonist Activity: Symmetry And Other Considerations Design Of Peptidomimetics The Fate Of Xenobiotics In Living Organisms Biotransformation Reactions Chemical Mechanisms Of Toxicity Basic Knowledge For Designing Safer Drugs Designing Prodrugs And Bioprecursors Macromolecular Carriers For Drug Targeting Preparation Of Water Soluble Compounds Through Salt Formation Preparation Of Water-Soluble Compounds By Covalent Attachment Of Solubilizing Moieties Drug Solubilization With Organic Solvents, Surfactants And Lipids Improvement Of Drug Properties By Cyclodextrins Chemical And Physicochemical Solutions To Formulation Problems Discover A Drug Substance, Formulate And Develop It To A Product Drug Nomenclature Legal Aspects Of Product Protection The Consumption And Production Of Pharmaceuticals. Bookseller Inventory # ABE_book_new_0127444815

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 83.17
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

3.

Camille Georges Wermuth (Editor)
Published by Academic Press (2003)
ISBN 10: 0127444815 ISBN 13: 9780127444819
New Hardcover Quantity Available: 1
Seller
Ergodebooks
(RICHMOND, TX, U.S.A.)
Rating
[?]

Book Description Academic Press, 2003. Hardcover. Book Condition: New. 2. Bookseller Inventory # DADAX0127444815

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 79.20
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

4.

Published by Academic Press (2003)
ISBN 10: 0127444815 ISBN 13: 9780127444819
New Hardcover Quantity Available: 1
Seller
Irish Booksellers
(Rumford, ME, U.S.A.)
Rating
[?]

Book Description Academic Press, 2003. Hardcover. Book Condition: New. book. Bookseller Inventory # 0127444815

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 166.69
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

5.

Wermuth
ISBN 10: 0127444815 ISBN 13: 9780127444819
New Quantity Available: 1
Seller
firstbookstore
(New Delhi, India)
Rating
[?]

Book Description Book Condition: Brand New. Brand New Original US Edition, Perfect Condition. Printed in English. Excellent Quality, Service and customer satisfaction guaranteed!. Bookseller Inventory # AIND-88411

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 205.05
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

6.

Wermuth
ISBN 10: 0127444815 ISBN 13: 9780127444819
New Quantity Available: 2
Seller
Bookshub
(Karol Bagh, India)
Rating
[?]

Book Description Book Condition: New. New. US edition. Perfect condition. Ship by express service to USA, Canada, Australia, France, Italy, UK, Germany and Netherland. Customer satisfaction our priority. Bookseller Inventory # ABE-190516-41172

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 207.44
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

7.

Wermuth
ISBN 10: 0127444815 ISBN 13: 9780127444819
New Quantity Available: 2
Seller
EBOOKSTORE2010
(New Delhi, ND, India)
Rating
[?]

Book Description Book Condition: Brand New. New. US edition. Customer Satisfaction guaranteed!!. Bookseller Inventory # SHAK41172

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 207.49
Convert Currency

Add to Basket

Shipping: FREE
From India to U.S.A.
Destination, Rates & Speeds

8.

Wermuth
ISBN 10: 0127444815 ISBN 13: 9780127444819
New Quantity Available: 1
Seller
Romtrade Corp.
(STERLING HEIGHTS, MI, U.S.A.)
Rating
[?]

Book Description Book Condition: New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery. Bookseller Inventory # AUSBNEW-88411

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 214.06
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

9.

Wermuth
ISBN 10: 0127444815 ISBN 13: 9780127444819
New Quantity Available: 1
Seller
Basi6 International
(Irving, TX, U.S.A.)
Rating
[?]

Book Description Book Condition: Brand New. Ships from multiple locations. FedEx or DHL 4-6 business days delivery to your doorstep. Bookseller Inventory # 20JULY16APP-2511

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 214.07
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

10.

Camille Georges Wermuth
Published by Academic Press (2003)
ISBN 10: 0127444815 ISBN 13: 9780127444819
New Hardcover Quantity Available: 1
Seller
Revaluation Books
(Exeter, United Kingdom)
Rating
[?]

Book Description Academic Press, 2003. Hardcover. Book Condition: Brand New. 2nd edition. 624 pages. 11.00x8.75x1.75 inches. In Stock. Bookseller Inventory # zk0127444815

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 352.03
Convert Currency

Add to Basket

Shipping: US$ 7.40
From United Kingdom to U.S.A.
Destination, Rates & Speeds

There are more copies of this book

View all search results for this book