Provides a concise and coherent account of the nature, structure and assembly of chromatin and its involvement in the processes of DNA transcription, replication and repair. The book constantly interrelates the structure of eukaryotic DNA with the nuclear processes it undergoes.
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Chromatin is the basic structural matrix of the eukaryotic chromosome and understanding its structure and function is essential to fully comprehend the mechanisms of gene regulation and the replication and recombination of DNA in higher organisms.
This Third Edition ofChromatin: Structure and Function brings the reader up-to-date with the remarkable progress in chromatin research over the past three years. It has been extensively rewritten to cover new material on chromatin remodeling, histone modification, nuclear compartmentalization, DNA methylation, and transcriptional co-activators and co-repressors. Also featured in this third edition are 60 new illustrations.
Written in a clear and concise fashion, Chromatin: Structure and Function is essential reading for advanced undergraduates, postgraduates and newcomers to the fields of biochemistry, cell biology, and molecular genetics.
Alan P. Wolffe is Chief of the Laboratory of Molecular Embryology and of the Section on Molecular Biology at the National Institute of Child Health and Human Development. He was educated in the UK, studying biochemistry at Oxford and completing graduate research with the Medical Research Council in London before moving to the United States. After a post-doctoral fellowship funded by the European Molecular Biology Organization at the Carnegie Institution of Washington, Dr. Wolffe joined the National Institutes of Health in 1988. His research interests include the earliest events in vertebrate development, with respect to the mechanisms through which nucleic acid binding proteins influence gene expression.
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Book Description Academic Pr, 1992. Paperback. Book Condition: New. Bookseller Inventory # DADAX0127619119