Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization

0 avg rating
( 0 ratings by Goodreads )
 
9780128010761: Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
View all copies of this ISBN edition:
 
 

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property.

Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

  • Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry
  • Includes expanded coverage of pharmacokinetics fundamentals and effects
  • Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

"synopsis" may belong to another edition of this title.

About the Author:

Li Di is an Associate Research Fellow at Pfizer, USA

"About this title" may belong to another edition of this title.

Buy New View Book
List Price: US$ 200.00
US$ 151.19

Convert currency

Shipping: FREE
From United Kingdom to U.S.A.

Destination, rates & speeds

Add to Basket

Top Search Results from the AbeBooks Marketplace

1.

Li Di
Published by Elsevier Science Publishing Co Inc, United States (2016)
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Hardcover Quantity Available: 1
Seller:
The Book Depository
(London, United Kingdom)
Rating
[?]

Book Description Elsevier Science Publishing Co Inc, United States, 2016. Hardback. Condition: New. 2nd edition. Language: English . Brand New Book. Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Seller Inventory # AA59780128010761

More information about this seller | Contact this seller

Buy New
US$ 151.19
Convert currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, rates & speeds

2.

Li Di
Published by Elsevier Science Publishing Co Inc, United States (2016)
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Hardcover Quantity Available: 1
Seller:
Book Depository International
(London, United Kingdom)
Rating
[?]

Book Description Elsevier Science Publishing Co Inc, United States, 2016. Hardback. Condition: New. 2nd edition. Language: English . Brand New Book. Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Seller Inventory # AA59780128010761

More information about this seller | Contact this seller

Buy New
US$ 158.91
Convert currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, rates & speeds

3.

Di, Li; Kerns, Edward H
Published by Academic Press
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Hardcover Quantity Available: 1
Seller:
WFL
(Holtsville, NY, U.S.A.)
Rating
[?]

Book Description Academic Press. Hardcover. Condition: New. 0128010762 Brand New ,Original Book , Direct from Source , Express 6-8 business days worldwide delivery. Seller Inventory # RB#BF151634

More information about this seller | Contact this seller

Buy New
US$ 170.22
Convert currency

Add to Basket

Shipping: US$ 4.90
Within U.S.A.
Destination, rates & speeds

4.

Li Di (author), Edward H Kerns (author)
Published by Elsevier Science 2016-02-25, Amsterdam (2016)
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Hardcover Quantity Available: > 20
Seller:
Blackwell's
(Oxford, OX, United Kingdom)
Rating
[?]

Book Description Elsevier Science 2016-02-25, Amsterdam, 2016. hardback. Condition: New. Seller Inventory # 9780128010761

More information about this seller | Contact this seller

Buy New
US$ 176.19
Convert currency

Add to Basket

Shipping: US$ 7.65
From United Kingdom to U.S.A.
Destination, rates & speeds

5.

Di, Li
Published by Academic Press (2016)
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Paperback Quantity Available: 1
Print on Demand
Seller:
Ria Christie Collections
(Uxbridge, United Kingdom)
Rating
[?]

Book Description Academic Press, 2016. Paperback. Condition: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Seller Inventory # ria9780128010761_lsuk

More information about this seller | Contact this seller

Buy New
US$ 181.01
Convert currency

Add to Basket

Shipping: US$ 4.93
From United Kingdom to U.S.A.
Destination, rates & speeds

6.

Li Di, Edward H. Kerns
Published by Academic Press Inc 2016-02-23 (2016)
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Quantity Available: 5
Seller:
Chiron Media
(Wallingford, United Kingdom)
Rating
[?]

Book Description Academic Press Inc 2016-02-23, 2016. Condition: New. Brand new book, sourced directly from publisher. Dispatch time is 3-4 working days from our warehouse. Book will be sent in robust, secure packaging to ensure it reaches you securely. Seller Inventory # NU-ELSPD-00006901

More information about this seller | Contact this seller

Buy New
US$ 147.94
Convert currency

Add to Basket

Shipping: US$ 38.14
From United Kingdom to U.S.A.
Destination, rates & speeds

7.

Li Di; Edward H. Kerns
Published by Academic Press (2016)
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Hardcover Quantity Available: 1
Seller:
Rating
[?]

Book Description Academic Press, 2016. Condition: New. Seller Inventory # L9780128010761

More information about this seller | Contact this seller

Buy New
US$ 193.97
Convert currency

Add to Basket

Shipping: US$ 3.15
From Germany to U.S.A.
Destination, rates & speeds

8.

Edward Kerns
Published by Oxford Elsevier LTD Feb 2016 (2016)
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Quantity Available: 1
Seller:
Rating
[?]

Book Description Oxford Elsevier LTD Feb 2016, 2016. Buch. Condition: Neu. Neuware - Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors' recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods 560 pp. Englisch. Seller Inventory # 9780128010761

More information about this seller | Contact this seller

Buy New
US$ 193.97
Convert currency

Add to Basket

Shipping: US$ 13.74
From Germany to U.S.A.
Destination, rates & speeds

9.

DI, LI; KERNS, EDWARD
Published by Academic Press (2016)
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Hardcover Quantity Available: 1
Seller:
Herb Tandree Philosophy Books
(Stroud, GLOS, United Kingdom)
Rating
[?]

Book Description Academic Press, 2016. Hardback. Condition: NEW. 9780128010761 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. For all enquiries, please contact Herb Tandree Philosophy Books directly - customer service is our primary goal. Seller Inventory # HTANDREE01617327

More information about this seller | Contact this seller

Buy New
US$ 199.33
Convert currency

Add to Basket

Shipping: US$ 10.20
From United Kingdom to U.S.A.
Destination, rates & speeds

10.

Edward Kerns
Published by Oxford Elsevier LTD Feb 2016 (2016)
ISBN 10: 0128010762 ISBN 13: 9780128010761
New Quantity Available: 1
Seller:
Rheinberg-Buch
(Bergisch Gladbach, Germany)
Rating
[?]

Book Description Oxford Elsevier LTD Feb 2016, 2016. Buch. Condition: Neu. Neuware - Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors' recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods 560 pp. Englisch. Seller Inventory # 9780128010761

More information about this seller | Contact this seller

Buy New
US$ 193.97
Convert currency

Add to Basket

Shipping: US$ 19.61
From Germany to U.S.A.
Destination, rates & speeds

There are more copies of this book

View all search results for this book