A new volume in the Emerging Issues in Analytical Chemistry series, Methods and Advances in Traditional Chinese Medicine describes analytical chemistry methods used to characterize constituents of herbal remedies, explore their mechanisms of action singly and in concert, and support the clinical trials necessary to bring Traditional Chinese Medicine (TCM) into the mainstream of therapeutics. With recent advances in analytical instruments, molecular pharmacology, and genetics, it is now possible to investigate the bioactive molecules in a complex medicine on a rational basis. This book is the first to combine TCM with analytical chemistry methods toward this goal.
The book begins with a brief history of TCM, consideration of its strengths and weaknesses, and a review of the literature on application of Western analytical methods. It continues with an examination of the concept of synergistic, multi-targeted action among components, followed by an analysis of how analytical chemistry and other methods are used to assure quality and uniformity of natural products within tolerable limits. It then addresses the complexity introduced by absorption, distribution, and metabolism of an already complex drug. The last chapter advocates a system biological approach as the way forward for drug discovery and development in TCM.
The Emerging Issues in Analytical Chemistry series is published in partnership with RTI International and edited by Brian F. Thomas. Please be sure to check out our other featured volumes:
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Dr. Lee has more than 40 years of experience in natural products chemistry, with a focus on Chinese herbal medicine. He has been principal investigator for numerous laboratory and clinical research studies funded by the U.S. National Institutes of Health and other agencies. He has been director of the Bio-Organic and Natural Products Research Laboratory since its foundation in 1999, has published 110 papers and 2 book chapters, and holds 15 patents. He is associate editor of Traditional Chinese Medicine and Journal of Traditional and Complementary Medicine.
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