Organic Chemistry (3rd Edition)

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9780130178589: Organic Chemistry (3rd Edition)

For full-year courses in organic chemistry taken by science and pre-health professions majors. This innovative text from acclaimed educator Paula Bruice is organized in a way that discourages rote memorization. It highlights mechanistic similarities and ties synthesis and reactivity together-teaching the reactivity of a functional group and the synthesis of compounds obtained as a result of that reactivity. Bruice's writing has been praised for anticipating students' questions and appeals to their need to learn visually and by solving problems. Emphasizing that students should reason their way to solutions rather than memorize facts, Bruice encourages students to think about what they have learned previously and apply that knowledge in a new setting. The text balances coverage of traditional topics with bioorganic chemistry, recognizing the importance of bioorganic topics to today's students.

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From the Back Cover:

Marine organisms like Tubestra, shown on the front cover, are a rich source of organic compounds with interesting and potent biological activity. Organic compounds derived from such living sources are called natural products.

Bengamide A comes from an orange encrusting sponge. This compound, as well as a host of analogs, has unique anti-tumor properties currently being exploited to develop new anticancer agents. Jasplakinolide, also found in a sponge, modulates the formation and depolymerization of actin microtubules ubiquitous to all cells. This compound has been used to improve our understanding of biological processes like cell division.

A closer look at these compounds reveals some fascinating elements of molecular architecture. There are six chirality centers in each of these molecules (Chapter 4). Also present in each are novel amino acid (Chapter 21) and lipid (Chapter 24) derivatives. The distinct biological activity of both molecules has motivated synthetic chemists worldwide to plan and execute elegant total syntheses (Chapter 29). These are just two of many examples of how natural products are key players in contemporary research linking organic chemistry to other disciplines.

About the Author:

PAULA YURKANIS BRUICE was raised primarily in Massachusetts, Germany, and Switzerland and was graduated from the Girls' Latin School in Boston. She received an A.B. from Mount Holyoke College and a Ph.D. in chemistry from the University of Virginia. She received an NIH postdoctoral fellowship for postdoctoral study in biochemistry at the University of Virginia Medical School, and she held a postdoctoral appointment in the Department of Pharmacology at Yale Medical School.

She has been a member of the faculty at the University of California, Santa Barbara since 1972, where she has received the Associated Students Teacher of the Year Award, the Academic Senate Distinguished Teaching Award, and two Mortar Board Professor of the Year Awards. Her research interests concern the mechanism and catalysis of organic reactions, particularly those of biological significance. Paula has a daughter and a son who are physicians and a son who is a lawyer. Her main hobbies are reading mystery/suspense novels and her pets (two dogs, two cats, and a parrot).

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