Lewin, Benjamin Genes VIII

ISBN 13: 9780131439818

Genes VIII

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9780131439818: Genes VIII

For courses in Molecular Biology, Molecular Genetics, and Gene Regulation. Two decades ago Benjamin Lewin's Genes revolutionized the teaching of molecular biology and molecular genetics by introducing a unified approach to bacteria and higher organisms. Genes has remained at the cutting edge of molecular biology, covering gene structure, organization, and expression. Originally the text opened with the genetic code and worked toward genome structure. Genes VIII changed the approach to begin with the sequence of the human and other genomes and starts with complete coverage of recent advances in genomics. The coverage of genomics is then integrated throughout the text. In striving to maintain currency, the new edition has updated coverage on genome organization, DNA replication, gene regulation and many other new topics.

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Two decades ago Benjamin Lewin's Genes revolutionized the way we think about and teach molecular biology and molecular genetics. His approach unified the discipline by providing an integrated account of the structure and function of genes in both prokaryotes and eukaryotes.

Setting a standard for currency, Genes continually embraces emerging trends in this field, such as introducing the molecular aspect of the gene before the traditional analysis of formal genetics. Genes VIII continues to innovate; expanding the early discussion of the genome and integrating new information on gene sequencing throughout the text.

New Content
  • Human and mouse genome sequence data incorporated throughout
  • Integrated coverage of recent advances in genomics and gene organization
Updated Content
  • DNA replication, repair, and recombination
  • Transcription and translation
  • Cancer and signal transduction

Genes VIII includes access to an innovative Website featuring a complete E-book with Flash illustrations. The text will be continuously updated online, providing coverage of the most recent advances in the field. Links to primary research articles are available whenever possible. (www.prenhall.com/lewin)

Excerpt. © Reprinted by permission. All rights reserved.:

With this eighth edition of GENES, 20 years have passed since the first edition. A novel feature of that first edition was the a presentation of prokaryotic and eukaryotic work in the context of a unified approach. Such an approach has now become commonplace as a result of along string of discoveries showing similarities in solutions to arc'-biological problems that often extend across many or even all species.

This new edition has been extensively revised and reorganized. The two most striking driving forces for change have been the sequencing of many genomes, providing information that permeates many sections of the book, and the availability of crystal structures, which in many cases replaces speculations about mechanism with detailed views.

A major change in presentation is made possible by the advent of the internet. A continuously updated version of GENES is maintained at www.ergito.com. Aside from some obvious differences in presentation, which allow the reader to customize a variety of views, the web version cites references within the text (compared with at the end of each chapter in the print version), and of course the citations are hyperlinked to original source material wherever possible. A concordance allows readers to find the section of the web site that is equivalent to any print section of the book (or vice versa).

A word is in order about the choice of references. With widespread adoption of policies that allow free access to material after a reasonable delay, the advantages to the scientific community for transparency in access have been made abundantly clear. In these circumstances, I do not regard publications in journals that neither adopt this policy nor are widely available (often because they are unreasonably expensive) as legitimate contributions to the scientific literature. I see no point in citing publications to which many readers will not have access. References are cited at the end of each chapter, organized by sections, and are classed into reviews (rev), research articles (ref), and accounts by authors of classic experiments on the ergito web site (exp).

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