Introduction to Biomedical Engineering (2nd Edition)

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9780136020035: Introduction to Biomedical Engineering (2nd Edition)

KEY BENEFIT: Substantial yet reader-friendly, this introduction examines the living system from the molecular to the human scale–presenting bioengineering practice via some of the best engineering designs provided by nature, from a variety of perspectives. Domach makes the field more accessible, helping readers to pick up the jargon and determine where their skill sets may fit in. KEY TOPICS: Cellular and Molecular Building Blocks of Living Systems; Mass Conservation, Cycling, and Kinetics; Requirements and Features of a Functional and Coordinated System; Bioenergetics; Molecular Basis of Catalysis and Regulation; Analysis of Molecular Binding Phenomena; Applications and Design in Biomolecular Technology; Metabolic and Tissue Engineering; Primer on Tissues and Organs; Biomechanics; Biofluid Mechanics; Biomaterials; Pharmacokinetics; Noninvasive Sensing and Signal Processing. MARKET: A useful resource for anyone interested in joining the field or learning more about bioengineering.

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From the Back Cover:

This text has three aims:

  • Explain the range of bioengineering activity in order to orient starting engineering students.
  • Provide a sense of how engineering differs from science.
  • Present some achievable depth on some salient science and engineering facets that drive a cross section of bioengineering practice.

Emphasis is placed on biomedical engineering, while also providing some material that is relevant to bioresource engineering and biochemical engineering.

The level of the discussion and homework problems are geared to freshmen college students who possess backgrounds in basic chemistry and physics. Chapters are provided that cover some highlights of modern biology and physiology to even out the life science backgrounds of the students. A chapter that explains how quantitative analysis is performed is often preceded by a chapter that provides a pictorial description of important phenomena. The mathematical level is primarily algebraic, but repeated use of some calculus techniques (e.g., optimization, separation of variables) in different problem contexts is done to challenge students with advanced placement and to motivate others on the relevance of their concurrent coursework in mathematics.

The first half of the book covers molecular- and cell-level phenomena, and applications featuring

  • Enzyme-based diagnostic technology
  • Metabolic engineering
  • Tissue Engineering

The second half of the text covers human-scale bioengineering featuring biomechanical, biomaterial, and electrical sensing applications such as

  • Human locomotion analysis and pace optimization
  • Branching in the circulatory system and pressure management
  • Magnetic resonance and signal processing basics

About the Author:

Michael M. Domach received a BS in chemical engineering from the University of Massachusetts at Amherst in 1978. His elective studies focused on organic and environmental chemistry. Immersion in life science and bioengineering occurred during his Ph.D. work at Cornell University under the supervision of Professor Michael L. Shuler. His academic career began in 1983 and has been spent at Carnegie Mellon University. His industrial experience includes working with organic chemists at General Electric to develop new product synthesis routes and cofounding a company involved in directing the growth and differentiation of stem cells. Professor Domach currently is a member of the chemical and biomedical engineering departments at Carnegie Mellon. Additionally, he served as the department head of biomedical engineering for 8.5 years and worked twice as a program director at the National Science Foundation (2000—2001; 2004—2005). The author’s research focuses on cell sensing, biocomputation, and cell engineering. In 2000, an article that was published in 1984, based on work from his Ph.D. thesis, was voted to be among the top 20 most influential publications that have appeared over the last 40 years in the journal Biotechnology and Bioengineering. In 2003, an article he wrote with one of his first graduate students on biological network analysis was denoted in a review as one of the first constraint-type models to be developed and fruitfully applied to discriminating between alternative physiology-based hypotheses. His subsequent publications on (1) using NMR to investigate live cells and (2) probing via electrical impedance arrays the response of cellular adhesion to drugs have been adopted for use in other engineering and biophysics textbooks. He has been elected a Fellow of the American Institute of Biological and Medical Engineers. Outdoor activities engage him when he is not working at Carnegie Mellon. He owns and manages a timberland in Weld, ME, and is a member of the Maine Forest Owners Association. The author keeps his other two camps in shape as well, which has fostered some improvement in his carpentry skills. One camp is located in Maine on Peabody Pond and the other is situated within the Sproul State Forest

(Pennsylvania). He has completed two backpacking trips in Alaska. One was conducted in The Gates of the Arctic, where the Brooks Range meets the tundra. That trip included a hitchhiked flight aboard a mail plane to the Nunamiut Eskimo/Inuit village, Anaktuvak Pass. Additionally, with another engineering colleague, Gary Powers, and other friends, he has visited the James Bay region of Quebec and Ontario each summer for about 20 years. There, good fishing and vivid northernlight displays have generated fine memories and time to think up new things to investigate.

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