Design of Enzyme Inhibitors as Drugs (v. 1)

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9780192615374: Design of Enzyme Inhibitors as Drugs (v. 1)
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This book presents authoritative accounts of the major target enzymes and their inhibitors which are currently the focus of research. The introductory chapters describe the underlying physical and chemical processes of enzyme inhibition and the general principles of inhibitor design using the many sophisticated and computer-based techniques that are now available. Subsequent chapters discuss in detail the wide range of individual target enzymes and inhibitors, emphasizing the factors which affect their usefulness in the clinical context: bioavailability, pharmacokinetics and side-effects.

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Sandler, Merton; Smith, H. John
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