Sickle cell disease was one of the first diseases to be explained at the molecular level. In the years since the first edition of this book was published, further advances have been made, and much has been learned about the causes of variation in the natural history of the disease and in the patterns of morbidity and mortality. The role of genetic modifiers such as alpha-thalassemia and persisting high levels of fetal hemoglobin, and of the beta-globin haplotype, have been recognized and explored. Studies of the disease which compare geographically separated populations have contributed to understanding this variability. These studies have led to more rigorous thinking about the nature of the disease and a clearer appreciation of how to manage it. This new edition contains many new references and incorporates the latest thinking on the biology and management of the disease.
"synopsis" may belong to another edition of this title.
Graham R Serjeant , Director, Medical Research Council Laboratories (Jamaica), University of the West Indies, Kingston, JamaicaReview:
" . . . this remains an excellent overview of sickle cell disease. It is well written and easy to read . . . I would consider this an excellent purchase for those with an interest in sickle cell disease." * ACP News *
"About this title" may belong to another edition of this title.
Book Description Oxford University Press, 1992. Paperback. Book Condition: New. Never used!. Bookseller Inventory # P110192622315