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Most neurological lesions in cancer patients are progressive, have a profound influence on the quality of life and can be fatal. Management of the situation requires rapid identification of the nature and location of the problem as the treatment outcome depends as much on the speed of diagnosis as on the subsequent therapy. While modern neuroimages provides invaluable clues to the diagnosis, they need to be interpreted in the light of clinical data. The clinical examination remains the cornerstone of the differential diagnosis of neurological lesions affecting the cancer patient. Neurological disorders are a consequence not only of primary tumours of the central and peripheral nervous system but also of systemic malignancy. One in five patients with disseminated malignancy develop neurological complications other than neurogenic pain. The majority of neurological problems are a direct consequence of metastatic disease or the result of metabolic disorders. However, some disorders are due to anti-neoplastic treatments or the administration of drugs. The incidence of CNS infections and vascular lesions is also increased in malignant disease, and a small proportion of neurological disorders are paraneoplastic, resulting from a remote effect of cancer on the nervous system. This book, written by a neurologist and an oncologist, aims to help the clinician to identify and locate the underlying neurological lesion in a cancer patient, and to make a quick therapeutic decision. Diagnostic and therapeutic algorithms are included with an emphasis on the more common and potentially treatable conditions. It should be read by neuro-oncologists, medical oncologists, radiation therapists, neurosurgeons and all those involved in the management of cancer patients.
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Professor Jerzy Hildebrand Service de Neurologie Universite Libre de Bruxelles Hopital Erasme Route de Lennik 808 B- 1070 Brussels BELGIUM Tel: 00 32 2 555 33 46 Fax: 00 32 2 555 39 42 E-mail: email@example.com Dr Michael Brada The Institute of Cancer Research The Royal Marsden NHS Trust
Downs Road Sutton Surrey SM2 5PT Tel: 020 8642 6011 ext 3272 Fax: 020 8643 5468 E-mail: firstname.lastname@example.org
"It provides an excellent summary of the treatment options for primary and secondary tumours ... This is an interesting, well written book that is well referenced throughout." British Journal of Neurology 2002; 16 (1) " ... an excellent overview of the main treatment options for brain tumours based on a thorough review of the literature ... There are plenty of gems in this book to inform even the most experienced neurologists ... The strength of this book lies in the ability of the authors to condense many years of combined experience into a small number of succinct chapters and to clarify areas of controversy within the boundaries of the literature ... I would not hesitate to recommend it." Brain, 125 "The strength of the book lies clearly in the widespread experience of the two authors. They hae been able to include common and rarer neurological syndromes into an easily digestible and coherent clinical classification ... The depth of coverage of medical and radiation neuro-oncology, the excellent core reference list, and numerous useful illustrations and algorithms make this a "must have" book." JNNP "This is the first neuro-oncology text book that is problem oriented, and as such is most timely ... this book is recommended for the library of any oncology and neurology department." Annals of Oncology 13 "Hildebrand and Brada present the most important aspects of their clinical discipline to their readers, and I believe succeed very well in so doing. Personally, I enjoyed reading this text, and learned from the very personal and practical approach offered by two prominent European neuro-oncologists." Canadian Journal of Neurological Sciences
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