Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage Sensitive Ion Channels

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9780192632241: Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage Sensitive Ion Channels

A volume in the Molecular and Cellular Neurobiology series.
This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. Improved understanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states.
The first section of the book contains three chapters dealing with cation channels and provides an accessible, succinct and comprehensive account of what is known about the structures and the assembly and targeting of these multimeric proteins. The focus of the book then moves on to cover ligand-gated ion channels with two chapters on accetylcholine receptors. The final section of the book contains four chapters covering the excitatory and inhibitory amino acid receptors.
Receptor and Ion-Channel Trafficking provides an integrated overview of the significant recent advances in the field of molecular neurobiology and will be essential reading for all researchers in neuroscience, neurobiology, biochemistry, cellular and molecular biology.

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About the Author:

Stephen Moss is at MRC-LMCB and Department of Pharmacology, University College London, UK. Jeremy Henley is at MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, UK.

Review:

"The editors and authors have done an excellent job ... Moss and Henley make a valuable contribution by highlighting major advances in the membrane trafficking of specific neurotransmitter receptors and ion channels ... this book is a most interesting and thought-provoking read." Nature Cell Biology

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