The Synaptic Organization of the Brain

ISBN 13: 9780195062557

The Synaptic Organization of the Brain

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9780195062557: The Synaptic Organization of the Brain

The third edition of The Synaptic Organization of the Brain continues the tradition of earlier editions in focusing on the principles underlying the organization of neurons and synapses into functional circuits within the best-studied regions of the brain: autonomic ganglia, spinal cord, olfactory bulb, retina, cerebellum, thalamus, basal ganglia, olfactory cortex, hippocampus, and neocortex. To ensure authoritative coverage of each area, the chapters have been revised by leading researchers. Nevertheless, as in past editions, each chapter follows the same format: neural elements, synaptic connections, basic circuits, physiological properties, neurotransmitters, and dendritic properties. In addition, each chapter now has a concluding section which discusses functional implications. This organization gives a logical structure to the description of each region, and greatly facilitates comparisons between regions and identification of common principles. Highlights include the first comprehensive attempt to incorporate intrinsic excitable membrane properties into neural circuits throughout the brain, the latest experimental results from patch recordings, brain slices, intracellular labelling, and 3-D reconstructions of neurons and connections. The book also provides summaries of neurotransmitters, neuromodulators, second-messengers and ligand-and voltage-gated membrane channels for each brain region. Up-to-date information on mechanisms underlying development and plasticity in brain circuits is also included as are computer methods for modeling neurons and circuits as a first step toward a "biophysics of neural computation."

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About the Author:

Gordon M. Shepherd, Professor of Neuroscience and Neurobiology, Yale University School of Medicine.


From reviews of previous editions:

"This is...a reference textbook that has served generations of neuroscientists at all levels of their career for a quarter century. It is like a wise and trusted mentor, who is always there for you...The marvel of the book in all editions is how much information is packed into such a small number of pages, yet it is comprehensible...any college or university instructor who teaches neurobiology ought to read this book, for it provides a depth of knowledge and perspective that cannot be gained from a (bad) strategy of knowing the course textbook cold and staying a few chapters ahead of one's students."--Contemporary Psychology

"The book remains a staple, and should be on the shelf of any serious neuroscientist."--The Quarterly Review of Biology

"By any measure this work is a classic...It will undoubtedly take its place as one of the most significant and comprehensive commentaries of our time on structure and function of nervous tissue."--Electroencephalography and Clinical Neurophysiology

"This well-organized volume clearly summarizes knowledge of neuronal interaction in several brain regions and assimilates new findings to the classical view of neuron communication."--Journal of the American Medical Association

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