Immunophysiology: The Role of Cells and Cytokines in Immunity and Inflammation - Softcover

Oppenheim, Joost J.; Shevach, Ethan M.

9780195070644: Immunophysiology: The Role of Cells and Cytokines in Immunity and Inflammation

Softcover

ISBN 10: 019507064X ISBN 13: 9780195070644

Publisher: Oxford University Press, 1991

This exciting new text describes how cells normally regulate immunological and inflammatory reactions, and how the immune system is intimately related to other bodily functions. The authors consider the effects of lymphokines on non-inflammatory cells and tissues, including connective tissue and the neuroendocrine system, and describe the effects of neuroendocrine and peptide growth factors produced by non-inflammatory cells and tissues on the functions of immune cells. To highlight the factors regulating immunophysiological functions, they discuss the inflammatory consequences of endotoxin, immune complexes, and complement; the interactions of immunomodulating epidermal factors and immune tissue; the modulation interactions of immunomodulating epidermal factors and immune tissue; and the modulation of immunity by cytokines. The mechanisms by which the immune system normally contends with bacterial, viral or tumor challenges are examined, with an emphasis on basic concepts and key experimental results; and the cells directly involved in host-defense processes are discussed. Wherever possible, information about in vivo and in vitro human immune responses is presented.

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About the Author:

Joost J. Oppenheim is Chief, Laboratory of Molecular Immunoregulation at the National Cancer Institute. Ethan M. Shevach is Head of the Cellular Immunology Section, Laboratory of Immunology at the National Institute of Allergy and Infectious Disease, and editor of The Journal of Immunology.

Review:

"All chapters are well written with excellent reference lists. This work is highly recommended to both immunologists and pathologists, more importantly, it is recommended to any student in the health related professions because it ties the immune system to many other physiological processes."
--Immunological Investigations

"This book is extremely unique in summarizing the recent progress in the mechanisms of host defenses. . . . The text places a new focus on the immune system and its interaction with tissue and cells that are not considered part of the immune system. The text is well written and highlights
important aspects of cytokine research in an expanding subspecialty of immunology. . . . I highly recommend this book for clinical researchers interested in cytokine and inflammation research." --New Jersey Medicine

"A valuable and useful sourcebook for any research concerned with inflammation and cytokine production . . . An excellent value and deserves a place on the shelf of every cellular immunologist or cytokine aficionado." --The Quarterly Review of Biology

"Most welcome. . . .Every clinical oncologist working in the field of cytokines should read and inwardly digest this excellent book." --Annals of Oncology

"This book is certainly worth looking at . . . for graduate and postgraduate students of immunology, physiology or pathology wishing to get to grips with the complexities of immunophysiology." --Immunology Today

"A comprehensive analysis of the normal immunological processes. All chapters are well written, filled with supporting materials and selected references that allow the reader to find more detailed information on single topics. Overlap between the chapters is minimal. The book is designed for
readers who are familiar with classical immunology but since it offers useful and contemporary information it is also suitable for graduate students. Simply, it can be recommended for anyone involveds in the area, whether in basic or in clinical research." --Molecular Immunology

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