Medicinal Chemistry: A Molecular and Biochemical Approach

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9780195104561: Medicinal Chemistry: A Molecular and Biochemical Approach
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Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource.

Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered.

There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

"synopsis" may belong to another edition of this title.

About the Author:

Thomas Nogrady is at Concordia University.

Review:


"The third edition of this popular textbook remains unique, authoritative, comprehensive and readable. Through a systematic organization of drug targets, all the important human disease and major categories of drugs are discussed providing insights into drug mechanisms and approaches to drug discovery. I highly recommend this book."--Doody's


"...recognized for its readability and clear-honed pitch, as the authors delve deeply into the mechanical specifics of how drugs take action on the human body."--The Electric Review


"About this title" may belong to another edition of this title.

Other Popular Editions of the Same Title

9780195104554: Medicinal Chemistry: A Molecular and Biochemical Approach

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ISBN 10:  0195104552 ISBN 13:  9780195104554
Publisher: Oxford University Press, 2005
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9780195034004: Medicinal Chemistry: A Biochemical Approach

Oxford..., 1985
Softcover

9780195053692: Medicinal Chemistry: A Biochemical Approach

Oxford..., 1988
Softcover

9780195033991: Medicinal Chemistry: A Biochemical Approach

Oxford..., 1985
Hardcover

9780195053685: Medicinal Chemistry: A Biochemical Approach

Oxford..., 1988
Hardcover

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Book Description Oxford University Press Inc, United States, 2005. Paperback. Condition: New. 3rd Revised edition. Language: English. Brand new Book. Fully updated and rewritten by a basic scientist who is also a practising physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a betterunderstanding of drug design, will find this book an invaluable resource.Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles(mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are exained. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered.There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neurpharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated andligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book'sappeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level. Seller Inventory # AAV9780195104561

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