Top Drugs: Top Synthetic Routes (Oxford Chemistry Primers)

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9780198501008: Top Drugs: Top Synthetic Routes (Oxford Chemistry Primers)

Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.

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Dr John Saunders, Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA.

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"This is a good introduction to the synthetic chemistry required to fuel the pharmaceutical industry and should encourage students to pursue a career in this exciting field." -- Doody's


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Book Description Oxford University Press, United Kingdom, 2017. Paperback. Book Condition: New. Language: English . Brand New Book. Today s top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. Bookseller Inventory # AAU9780198501008

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Book Description Oxford University Press. Paperback. Book Condition: new. BRAND NEW, Top Drugs: Top Synthetic Routes, John Saunders, Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. Bookseller Inventory # B9780198501008

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Book Description Oxford University Press, United Kingdom, 2017. Paperback. Book Condition: New. Language: English . Brand New Book. Today s top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis. Bookseller Inventory # AAU9780198501008

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Book Description Oxford University Press, 2012. Book Condition: New. This title allows students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis. Series: Oxford Chemistry Primers. Num Pages: 96 pages, numerous line illustrations. BIC Classification: PN; TDCW. Category: (U) Tertiary Education (US: College). Dimension: 245 x 189 x 6. Weight in Grams: 198. . 2012. 1st Edition. Paperback. . . . . . Bookseller Inventory # V9780198501008

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Book Description Oxford University Press. Book Condition: New. This title allows students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis. Series: Oxford Chemistry Primers. Num Pages: 96 pages, numerous line illustrations. BIC Classification: PN; TDCW. Category: (U) Tertiary Education (US: College). Dimension: 245 x 189 x 6. Weight in Grams: 198. . 2012. 1st Edition. Paperback. . . . . Books ship from the US and Ireland. Bookseller Inventory # V9780198501008

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