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Problems with cellular lysosome function underlie a group of neurological disorders known as the storage diseases. These are inherited disorders, characterized by a failure to control the accumulation of internal cell products resulting in cell death. In recent years major advances in the fields of biochemistry and cell biology have expanded our understanding of these disorders. This book describes the molecular mechanisms and pathophysiological pathways involved and the potential for interventions aimed at treatment.
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Frances Platt is at Glycobiology Institute, Department of Biochemistry, University of Oxford, UK. Steven Walkley is in the Department of Neurosciences, Pathology and Neurology, Albert Einstein College of Medicine, New York, USA.Review:
"...this book is an excellent complement to encyclopedic textbooks. The high quality and new approach to the description of lysosomal disorders will attract the much-needed basic and clinical scientists and students to this important and exciting subject." --THE LANCET Neurology
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