Organic Chemistry: International Edition

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9780321853103: Organic Chemistry: International Edition
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All of Paula Bruice's extensive revisions to the Seventh Edition of Organic Chemistry follow a central guiding principle: support what modern students need in order to understand and retain what they learn in organic chemistry for successful futures in industry, research, and medicine. In consideration of today's classroom dynamics and the changes coming to the 2015 MCAT, this revision offers a completely new design with enhanced art throughout, reorganization of materials to reinforce fundamental skills and facilitate more efficient studying.

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From the Back Cover:

Marine organisms like Tubestra, shown on the front cover, are a rich source of organic compounds with interesting and potent biological activity. Organic compounds derived from such living sources are called natural products.

Bengamide A comes from an orange encrusting sponge. This compound, as well as a host of analogs, has unique anti-tumor properties currently being exploited to develop new anticancer agents. Jasplakinolide, also found in a sponge, modulates the formation and depolymerization of actin microtubules ubiquitous to all cells. This compound has been used to improve our understanding of biological processes like cell division.

A closer look at these compounds reveals some fascinating elements of molecular architecture. There are six chirality centers in each of these molecules (Chapter 4). Also present in each are novel amino acid (Chapter 21) and lipid (Chapter 24) derivatives. The distinct biological activity of both molecules has motivated synthetic chemists worldwide to plan and execute elegant total syntheses (Chapter 29). These are just two of many examples of how natural products are key players in contemporary research linking organic chemistry to other disciplines.

About the Author:

Paula Yurkanis Bruice was raised primarily in Massachusetts. After graduating from the Girls' Latin School in Boston, she earned an A.B. from Mount Holyoke College and a Ph.D. in chemistry from the University of Virginia. She then received an NIH postdoctoral fellowship for study in the Department of Biochemistry at the University of Virginia Medical School and held a postdoctoral appointment in the Department of Pharmacology at Yale Medical School. Paula has been a member of the faculty at the University of California, Santa Barbara since 1972, where she has received the Associated Students Teacher of the Year Award, the Academic Senate Distinguished Teaching Award, two Mortar Board Professor of the Year Awards, and the UCSB Alumni Association Teaching Award. Her research interests center on the mechanism and catalysis of organic reactions, particularly those of biological significance. Paula has a daughter and a son who are physicians and a son who is a lawyer. Her main hobbies are reading mystery and suspense novels and enjoying her pets (two dogs, two cats, and a parrot).

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