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Selective Sentinel Lymphadenectomy for Human Solid Cancer (Cancer Treatment and Research, 127) - Hardcover
Synopsis
First book to apply the concept of SSL to the majority of human cancers
Revolutionary new concept that might significantly transform surgical cancer treatment
Focuses on cancer metastasis and explores the biological frontier of micro metastasis
Includes illustrations by experts in the field on how to successfully perform SSL
"synopsis" may belong to another edition of this title.
From the Back Cover
Lymph node (LN) status is the most important prognostic indicator for the clinical outcome of patients in human solid cancer. Recent developments in sentinel lymph node (SLN) concept and technology have resulted in the application of this revolutionary approach to determine if cancer has metastasized. The underlying thesis in solid cancer biology is that metastasis generally starts in an orderly progression, often spreading through the lymphatic channels to the SLN. Thus, the logical approach is to harvest that specific SLN for thorough analysis.
The most exciting possibility of selective sentinel lymphadenectomy (SSL) is that it will lead to early diagnosis of micrometastasis in regional LNs. Early diagnosis makes it useful as a clinical staging procedure, and opens up new opportunities to study micrometastasis and its evolution within the SLNs.
New molecular and genetic tools may be used to dissect the mechanisms of lymphatic and hemotogenous routes of metastasis. If such mechanisms can be understood, new therapeutic advances may be developed to prevent the process of micrometastasis.
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Minimally invasive surgery associated with reduced morbidity has transformed the management of cancer patients. Sentinel lymphadenectomy for staging and treatment of solid tumors is now standard of care in many settings. In this text, distinguished investigators review the technical aspects and clinical considerations related to this procedure.
Steven T. Rosen, M.D.
Series Editor
Review
From the reviews:
"This is a current comprehensive book on sentinel lymphadenectomy ... . The book is written for the surgeon ... . This includes residents in training, surgical oncology fellows, and practicing surgeons. The written detail, supporting diagrams, and pictures provide a complete practice manual. ... A single book that contains 10 years of journal material is convenient and for those not following the literature invaluable. ... no other book has united several different diseases and explored them through the SLN concept." (Neal Wilkinson, Doody's Electronic Journal, May, 2005)
"About this title" may belong to another edition of this title.
- PublisherSpringer
- Publication date2005
- ISBN 10 0387236031
- ISBN 13 9780387236032
- BindingHardcover
- LanguageEnglish
- Number of pages320
- EditorLeong Stanley P. L., Kitagawa Yuko, Kitajima Masaki
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Selective Sentinel Lymphadenectomy for Human Solid Cancer,
Seller: CSG Onlinebuch GMBH, Darmstadt, Germany
Seller rating 5 out of 5 stars
hard bound, DVD included. Condition: Sehr gut. Gebraucht - Sehr gut about this book: In human solid cancer, the lymph node (LN) status is the most important prognostic indicator for the clinical outcome of patients. Recent developments in the sentinel lymph node (SLN) concept and technology have resulted in the application of this revolutionary approach to define the first draining or SLN to which the cancer may have metastasized. The underlying thesis in solid cancer biology is that metastasis generally starts in an orderly progression, spreading through the lymphatic channels to the SLN in the nearest LN basin. Thus, the logical approach is to harvest that specific SLN for thorough analysis. Because a tumor-free SLN is usually associated with a negative residual LN basin, a negative SLN is an excellent indication that micrometastasis has not occurred in the regional LNs. When the SLN is involved, it is unknown whether or not metastasis is limited only to the SLN or if the disease has spread to the remainder of the nodal basin. For this reason, if an SLN is positive, a complete lymph node dissection is recommended. Therefore, selective sentinel lymphadenectomy (SSL) should be considered as a staging procedure so that patients with negative SLNs (about 80%) may be spared an extensive LN dissection. Malignant melanoma has been proven to be the most ideal tumor model to study the role of SLN. Subsequently, SSL has been applied to breast cancer, colon cancer and other types of solid cancer. The multidisciplinary approach encompassing the surgeon, nuclear medicine physician, and pathologist is the key to such a successful procedure. Such a team can be formed readily with appropriate training. Beyond the technical aspects of harvesting the SLN, the implication of micrometastasis remains to be defined. Because the follow-up of melanoma and breast cancer patients after SSL is crucial, ongoing clinical trials are in progress to determine the biological and clinical significance of SLNs. Although the concept of SLN is viable in other types of cancer, such as gynecological and gastrointestinal, the technical aspects of the procedure need to be perfected and verified. The most exciting possibility of SSL is that it will lead to early diagnosis of micrometastasis in regional LNs. Early diagnosis makes it useful as a clinical staging procedure, and opens up new opportunities to study micrometastasis and its evolution within the SLNs. Examining the multifaceted aspects of micrometastasis, such as differentiation of different clones with respect to the primary tumor, acquisition of adhesion molecules, and host interaction with the microscopic tumor, will shed new light on the biology of early metastasis. New molecular and genetic tools may be used to dissect the mechanisms of lymphatic and hemotogenous routes of metastasis. If such mechanisms can be understood, new therapeutic advances may be developed to prevent the process of micrometastasis. Rather than targeting larger tumor burdens such as Stage IV disease, targeted adjuvant clinical trials can be developed for high risk patients following definitive surgical resection. SSL is a standard staging procedure for patients with melanoma and is rapidly evolving into a standard procedure for breast cancer as well. Written for: Nuclear medicine physicians, surgical oncologists, pathologists, and basic scientists interested in the biology of the lymphatic system. Seller Inventory # 20310
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Selective Sentinel Lymphadenectomy for Human Solid Cancer (Cancer Treatment and Research, 127)
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hardcover. Condition: Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority! Seller Inventory # S_408565725
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Selective Sentinel Lymphadenectomy For Human Solid Cancer
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Selective Sentinel Lymphadenectomy For Human Solid Cancer
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Selective Sentinel Lymphadenectomy for Human Solid Cancer
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Selective Sentinel Lymphadenectomy for Human Solid Cancer
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Selective Sentinel Lymphadenectomy for Human Solid Cancer
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Selective Sentinel Lymphadenectomy for Human Solid Cancer
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Condition: Sehr gut. Zustand: Sehr gut - Neubindung | Seiten: 297 | Sprache: Englisch | Produktart: Bücher. Seller Inventory # 1759069/12
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Selective Sentinel Lymphadenectomy For Human Solid Cancer (Cancer Treatment And Research)
Seller: Basi6 International, Irving, TX, U.S.A.
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Condition: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service. Seller Inventory # ABEJUNE24-84574
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Selective Sentinel Lymphadenectomy For Human Solid Cancer
Seller: Romtrade Corp., STERLING HEIGHTS, MI, U.S.A.
Seller rating 5 out of 5 stars
Condition: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide. Seller Inventory # ABNR-91229
Quantity: 1 available