The Collagens: Biochemistry and Pathophysiology

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9780387533230: The Collagens: Biochemistry and Pathophysiology

Quam magnijicata sunt opera tua, Domine! Omnia in sapientia feciti, plena est terra creaturis tuis. Psalm us CIV: XXIV. The days when the answer to the questions "What is collagen and what is it for?" was simple and short are gone. Nowadays, collagen cannot be considered as a single and metabolic inert fibrous protein responsible only for some mechanical proper ties of tissues. The family of collagen proteins increases rapidly, and new collagens are still being discovered. They differ each from the other, and only the basic amino acid sequence con taining proline and hydroxyproline is the one constant and unique feature of proteins which are very different in all other aspects. This heterogeneity is related to the variety of their bio logical functions. The list of physiological aspects involving collagens as well as the number of disorders associated with collagen abnormalities are expanding rapidly. The structure and function of almost every organ are in some way related to connective tissue and to collagens in particular. Our knowledge in this field is significantly growing but is still far from com plete. The efforts to modify collagen gene expression, structure, and metabolism in order to manage some disorders are a new goal of pharmacology and are a natural sequel of the progress ing understanding of the pathophysiological role of collagens. This book provides a comprehensive overview of the patho physiological aspects of collagens with special emphasis on medical problems, i. e.

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This book describes every manner in which collagen is involved in normal anddisease-altered states of the various organs and systems. In the first part of the book the biochemical aspects of collagens are reviewed, including their structure, heterogeneity, syntheses, and degradation. The main part focuses on the involvement of collagen in bone, cartilage, tendon, muscle, heart, vessels, lungs, liver, skin, eye, ear, teeth, periodontal tissues, kidneys and reproductive, hemopoietic,and nervous systems. The influence of radiation and nutrition on collagen, the role of collagen in neoplasms, the hormonal control of its metabolism, immunobiology and the pharmacology of collagen are also described. The most important feature of the book is the comprehensive review of the medical aspects of collagen, from those known in detail to those only hypothesized including hereditary disorders affecting collagen and so-called collagen diseases. Each chapter reviewsknown or possible mechanisms of collagen involvement and changes in indices of collagen which can be measured in clinical practice to monitor these phenomena. The fact that collagen is involved into the pathophysiology of almost all organs and body systems means that physicians in almost all branches of medicine will find this book of great interest.

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Kucharz Eugene J.
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ISBN 10: 0387533230 ISBN 13: 9780387533230
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Book Description Springer. Book Condition: New. pp. xvii + 430 , Illus. Bookseller Inventory # 58144369

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Eugene Joseph Kucharz
Published by Springer-Verlag (1992)
ISBN 10: 0387533230 ISBN 13: 9780387533230
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Book Description Springer-Verlag, 1992. Hardcover. Book Condition: New. 1. This item is printed on demand. Bookseller Inventory # DADAX0387533230

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