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This edition has increased clinical emphasis, providing the student with the necessary overview on how a class of drugs will be used in a clinical setting. The use of two colours helps to explain difficult concepts easily. The clinical text relating to the therapeutic use of drugs has been pulled out of the main text and put into boxes for emphasis. Also, a clinical pharmacologist has joined the author team (Professor Jim Ritter) to increase the clinical content of the book. The text aims to put pharmacology into the context of other science subjects. Many chapters have brief summaries of relevant physiological and biochemical processes at the beginning to form a basis for the subsequent treatment of pharmacological actions. "Key points boxes" are included in each chapter highlighting all the main facts and ideas. Clinical applications summary boxes reflect the book's increased emphasis on aspects of clinical pharmacology and the clinical use of drugs. This edition contains new chapters on nitric oxides, neurodegenerative disorders and on diabetes and the control of carbohydrate metabolism. There has been major updating of: aspects of receptor pharmacology and signal transduction; cardiovascular pharmacology, including atherosclerosis and the control of lipoprotein metabolism; drug interactions; drugs action on 5HT receptors; growth factors and cytokines; the biology of cancer; the course of HIV infections and approaches to treatment; the aetiology and treatment of peptic ulcers; cyclo-oxygenases and the action of NSAIDS. In addition there are 40 new illustrations and existing illustrations have been further enhanced by the use of colour.
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Professor HP Rang obtained his first degree in Physiology at University College London, and went on to graduate in Medicine before moving to the Department of Pharmacology in Oxford. There he gained a DPhil, and wasappointed to a University Lectureship in Pharmacology and a Fellowship at Lincoln College, Oxford. He became Professor and Head of Department at St George's Hospital Medical School and later at University College London, and he was Director of the Novartis (formerly Sandoz) Institute for Medical Research, based at University College. Professor Rang was elected a Fellow of the RoyalSociety in 1980. Since retiring in 1999, he has worked as a consultant to pharmaceutical and biotechnology companies. He has published many research papers, mainly in the fields of receptor pharmacology and neuroscience.
With Dr Maureen Dale he wrote the first edition of Pharmacology (1987),and Professor Jim Ritter became a co-author for the third and subsequent editions. He is currently preparing a new book on Drug Discovery, to be published by Harcourt.
Dr Dale is Senior Teaching Fellow in the Department of Pharmacology of the University of Oxford. Having graduated in Medicine at the University of the Witwatersrand in Johannesburg, South Africa, she worked as a medical officer at a Health Centre for several years before joining the staff of medical school of the University of Natal. There she was responsible for establishing ab initio, the first course in experimental/clinical pharmacology in South Africa. Finding herself in profound disagreement with the 'apartheid' government in South Africa, she emigrated to the UK where she joined the Department of Pharmacology of University College London. There she gained a PhD in pharmacology and was, for many years, responsible for running the pharmacology course for medical students and the immunopharmacology course for final year science students.
Dr Dale has been an editor of the British Journal of Pharmacology. Before retiring fromUCL in 1991, her research areas were the immunopharmacology of asthma and rheumatoid arthritis.
Professor Jim Ritter is Head of the Department of Clinical Pharmacology at Guy's King's and St Thomas' School of Medicine (King's College, London, UK). His first degree was in Animal Physiology and he obtained a D Phil in Pharmacology before completing clinical medicine at the Radcliffe Infirmary (Oxford). His basic medical training was in Oxford, London and the Johns Hopkins Hospital (Baltimore, USA), where he was chief resident for two years. Subsequent specialist training in clinical pharmacology was at Hammersmith Hospital (London). He is an honorary consultant physician at Guy's and St Thomas' NHS Trust where he shares in the acute general medical take, and sees outpatients in the hypertension and vascular disease prevention clinics. His research is in human vascular pharmacology, especially of endothelium-derived mediators. He sat on the sub-committee on safety and efficacy of CSM, has chaired local and multicentre research ethics committees, and currently chairs the Thames Specialty Training Committee in Clinical Pharmacology. He is one of the two editors of the British Journal of Clinical Pharmacology.
"Rang & Dale are now due more praise for their new improved version of Pharmacology. As before the writing is excellent and surely undergraduates can master a subject when it is explained so lucidly and with evident enthusiasm. As a comprehensive textbook for pharmacy or pharmacology students it has few rivals. As a guide to help continuing education in modern pharmacology it should be both useful and enjoyable." British Journal of Hospital Medicine
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