AIDS Therapy, 1e

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9780443075926: AIDS Therapy, 1e

This comprehensive new reference is an up-to-date source of concise guidance on the diagnosis and therapy of disorders associated with AIDS. Discussions encompass organ-based syndromes, pathogens, and the individual drugs used for therapy.

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About the Author:

Raphael Dolin, MD, Maxwell Finland Professor of Medicine (Microbiology & Molecular Genetics), Harvard Medical School; Attending Physician, Beth Israel Deaconess Medical Center Brigham and Women's Hospital, Boston, Massachusetts

From The New England Journal of Medicine:

The treatment of patients with AIDS is a maturing specialty that is now moving into its third decade. For this reason, it is timely to note the appearance of a work dedicated exclusively to therapies for the suppression of viral replication and for the opportunistic infections and cancers associated with AIDS. These treatments consist of increasingly complex regimens that involve a high risk of deleterious drug interactions.

First editions of any work reflect prodigious effort, and the lengthy process of preparation often results in some material's being outdated by the time of publication. In this work, however, the sections on antiretroviral agents and treatment strategies are up to date and complete. In addition to sections on the diagnosis of human immunodeficiency virus (HIV) infection and antiretroviral agents, there are sections on immune-based and alternative therapies. In-depth information is given on the structure, mechanism of action, pharmacokinetics, and toxicity of all therapeutic drugs, including the new arrivals abacavir and efavirenz, along with results of the relevant clinical trials. The second-generation protease inhibitors, such as the promising ABT-378, are mentioned only once, though. A short discussion of the treatment of children is included in many chapters on drugs, and an entire chapter is devoted to the management of AIDS in pregnant patients. Drug interactions and the problem of resistance, both important issues in clinical practice, are also addressed.

The diagnosis, therapy, and prevention of opportunistic infections are presented in a separate section, which is followed by another on the approach to specific syndromes. The chapters on opportunistic infections are excellent and, with few exceptions, mirror the state of the art. Discussion of some recent concepts -- such as interruption of prophylaxis against Pneumocystis carinii pneumonia or cytomegalovirus in patients with restored immunity, the impact of highly active antiretroviral therapy on the clinical manifestations of tuberculosis, and the use of new antifungal agents in refractory candidiasis -- is lacking, however.

AIDS Therapy is conveniently organized in sections that make it easy to use the book. The text is written in clear language, with well-chosen titles and subheadings, but the complexity, detail, and format of some tables and figures do not allow a rapid overview of the subject.

The authors have contributed comprehensive review articles; thus there is overlap between chapters. Nevertheless, if the book is used as a reference work, the completeness of each chapter is a definite advantage.

Updates to the text will be inevitable to maintain the relevance of this book to such an evolving specialty. The inclusion of a CD-ROM would have facilitated and accelerated consultation of the book's contents.

This comprehensive and up-to-date textbook on AIDS therapy will be welcomed by specialists, who will find -- in one volume -- detailed scientific overviews of options and strategies in treatment that are relevant to the clinician and that form a basis for scientific presentations.

Reviewed by N. Clumeck, M.D., Ph.D.
Copyright © 1999 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS.

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