Introduction to Protein Mass Spectrometry - Softcover

Ghosh, Pradip K.

Softcover

ISBN 10: 0443140154 ISBN 13: 9780443140150

Publisher: Academic Press, 2024

Synopsis

Introduction to Protein Mass Spectrometry, Second Edition provides a comprehensive overview of this increasingly important, yet complex, analytical technique. This book enables readers to understand how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. This new edition is fully updated to include the latest developments in the field and will feature new content covering recent progress in the areas where there have been the most exciting advances. These include PNNL’s multilevel-PCB-based SLIM realization, SLIM-Agilent QQQ field trials; employment of SLIM-IMS-cryo-IR combination in molecular structure determination; proximity-labelling mass spectrometry, and applications in neuroscience.

• Offers up-to-date, introductory information for scientists and researchers new to the field, as well as advanced insights into the critical assessment of computer-analyzed mass spectrometric results and their current limitations
• Provides examples of commonly used MS instruments from a range of key manufacturers/developers, including Bruker, Applied Biosystems, JEOL, Thermo Scientific/Thermo Fisher Scientific, IU, Waters and PNNL
• Includes biological applications and exploration of analytical tools and databases for bioinformatics
• Features definitions, case studies, and recent developments in protein mass spectrometry
• Includes sections new to this edition on SLIM (Structures for Lossless Ion Manipulation) and mass spectrometry applications in neuroscience, including synaptic biology and Alzheimer’s disease

About this title

About the Author

Pradip K. Ghosh received his PhD from Indiana University, USA, and did his postdoctoral research at Rice University. For most of his career he was on the faculty at the Indian Institute of Technology Kanpur, India. He also taught as a Visiting Professor at Pomona College and the University of California Berkeley. His research specialization has been in plasma chemical physics and in mass spectrometry. He is the author of several books, including Introduction to Photoelectron Spectroscopy (Wiley-Interscience), Ion Traps (Clarendon Press, Oxford), and the first edition of Introduction to Protein Mass Spectrometry (Academic Press).

From the Back Cover

Introduction to Protein Mass Spectrometry, Second Edition, provides a comprehensive overview of this increasingly important, yet complex, analytical technique. This book enables readers to understand how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. This new edition is fully updated to include the latest developments in the field and will feature new content covering recent progress in the areas where there have been the most exciting advances. These include PNNL’s multilevel-PCB-based SLIM realization, SLIM-Agilent QQQ field trials; employment of SLIM-IMS-cryo-IR combination in molecular structure determination; proximity-labelling mass spectrometry, and applications in neuroscience.

Citing the most recent and relevant work in the field of biological mass spectrometry, this book is written for researchers and scientists new to the field but is also an ideal resource for those hoping to hone their analytical abilities.

Edition details

• Publisher: Academic Press
• Publication date: 2024
• Language: English
• ISBN 10: 0443140154
• ISBN 13: 9780443140150
• Binding: Paperback
• Edition number: 2
• Number of pages: 386