Neurogenetics, Part I, Volume 147 (Handbook of Clinical Neurology)

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9780444632333: Neurogenetics, Part I, Volume 147 (Handbook of Clinical Neurology)

Genetic methodologies are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is evolving rapidly and expected to grow in scope as more disorders are linked to specific genetic markers. Part I covers basic genetic concepts and recurring biological themes, and begins the discussion of movement disorders and neurodevelopmental disorders, leading the way for Part II to cover a combination of neurological, neuromuscular, cerebrovascular, and psychiatric disorders. This volume in the Handbook of Clinical Neurology will provide a comprehensive introduction and reference on neurogenetics for the clinical practitioner and the research neurologist.

  • Presents a comprehensive coverage of neurogenetics
  • Details the latest science and impact on our understanding of neurological psychiatric disorders
  • Provides a focused reference for clinical practitioners and the neuroscience/neurogenetics research community

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About the Author:

Dr. Geschwind is the Gordon and Virginia MacDonald Distinguished Professor of Human Genetics, Neurology and Psychiatry at UCLA. In his capacity as Senior Associate Dean and Associate Vice Chancellor of Precision Health, he also leads Precision Health and Genomic Medicine activities in the UCLA Health System and David Geffen School of Medicine. His laboratory has pioneered the application of systems biology methods in neurologic and psychiatric disease, working in collaboration with dozens of other laboratories to connect molecular pathways to nervous system function. Dr. Geschwind has put considerable effort into fostering large-scale collaborative patient resources for genetic research and data sharing. He has served on numerous scientific advisory boards, including the Faculty of 1000 Medicine, the Executive Committee of the American Neurological Association, the Scientific Advisory Board for the Allen Institute for Brain Science, the NIMH Advisory Council and the NIH Council of Councils. He has published over 400 papers and serves on the editorial boards of Cell, Neuron and Science. He has received numerous awards and is an elected Member of the American Association of Physicians and the National Academy of Medicine.

Dr. Henry Paulson is the Lucile Groff Professor of Neurology for Alzheimer’s Disease and Related Disorders in the Department of Neurology at the University of Michigan. Dr. Paulson joined the U-M faculty in 2007, where he directs the programs in neurodegenerative diseases, the Michigan Alzheimer’s Disease Center and co-directs the University of Michigan Protein Folding Diseases Initiative. Dr. Paulson received his MD and PhD from Yale University in 1990, then completed a neurology residency and neurogenetics/movement disorders fellowships at the University of Pennsylvania. From 1997 to 2007, he was on the Neurology faculty at the University of Iowa. Dr. Paulson’s research and clinical interests concern the causes and treatment of age-related neurodegenerative diseases, with a focus on hereditary ataxias, polyglutamine diseases, and frontotemporal dementia. Dr. Paulson serves on the scientific advisory boards of numerous disease-related national organizations, and is past-Chair of the Board of Scientific Counselors at the National Institute for Neurological Disorders and Stroke at the National Institutes of Health.

Dr. Christine Klein is a Professor of Neurology and Neurogenetics. She studied medicine in Hamburg, Heidelberg, Luebeck (1988-1994), and London (with Dr. N.P. Quinn in 1994/1995). She moved to Boston from 1997-1999 for a fellowship in Molecular Neurogenetics under the mentorship of Dr. X.O. Breakefield. Dr. Klein completed her neurology training at Luebeck University with Dr. D. Koempf in 2004, followed by a series of summer sabbaticals in movement disorders with Dr. A.E. Lang in Toronto, Canada in 2004-2015. She was appointed Lichtenberg Professor at the Department of Neurology of Luebeck University in 2005, where her research has focused on the clinical and molecular genetics of movement disorders and its functional consequences. In 2009, Dr. Klein has been awarded a Schilling Section of Clinical and Molecular Neurogenetics at the University of Luebeck and has become Director of the newly founded Institute of Neurogenetics in 2013.
Dr. Klein has published over 400 scientific papers and is the 2008 recipient of the Derek Denny-Brown Award of the American Neurological Association. She is an Associate Editor of ‘Annals of Neurology’ and of ‘Movement Disorders’. She has served as chair of the Congress Scientific Program Committee of the 2016/2017 Annual Congresses of the International Parkinson and Movement Disorder Society and is President-Elect of the German Neurological Society.

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