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Prodrug design comprises an important area of drug research that is concerned with the optimization of drug delivery. The book presents the basic principles of drug design and illustrates these principles with numerous examples. It provides a comprehensive review of the most recent literature on prodrugs, and is the first book dealing exclusively and extensively with all aspects of design and application. The book contains 11 chapters, each chapter written by outstanding scientists in the field. The following topics are treated: A comprehensive classification and evaluation of types of bioreversible derivatives for various functional groups and chemical entities occurring in drug substances. Design of prodrugs based on enzyme-substrate specificity. Pharmacokinetic aspects of prodrug design and evaluation. Sustained drug action accomplished by the prodrug approach. Site-specific drug delivery via prodrugs. Decreased toxicity and adverse reactions via prodrugs. Prodrugs for improved skin absorption. Prodrugs in cancer chemotherapy. Albumin as a natural carrier for drugs and enzyme therapy. Prodrugs versus soft drugs
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Book Description Elsevier Science Ltd, 1985. Hardcover. Condition: New. Never used!. Seller Inventory # P11044480675X
Book Description Elsevier Science Ltd, 1985. Condition: New. book. Seller Inventory # M044480675X