New Drug Discovery and Development

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9780470007501: New Drug Discovery and Development
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A case history approach to drug synthesis and discovery

Discover the origins of some of today’s most popular drugtherapies. Explore case histories and gain insight into majorclasses of antibiotics, antiviral drugs, analgesics, steroids,compounds designed to lower cholesterol, and more. Review the stepsrequired for FDA approval.  This is a great reference forstudents in medicinal chemistry, researchers in pharmaceuticals,and medical practitioners.

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A case history approach to drug synthesis and discovery

Discover the origins of some of the most popular drug therapieson the market today, including penicillin, Minoxidil, Viagra®,and "the pill." This guide to drug synthesis and discovery focuseson case histories. Organized by drug category, the guide introducesreaders to the rich interplay of research and serendipity that isresponsible for many commonly prescribed drugs today. Moreover, theauthor demonstrates how the discovery and development of a new drugor drug category creates a domino effect, leading to thedevelopment of newer therapeutics as pharmaceutical companiescompete to satisfy market demands.

Readers gain new insight from both a chemical and medicalperspective into:

  • Major classes of antibiotics used to treat infectiousdiseases
  • Antiviral drugs, including recent antiviral compounds designedto take advantage of new findings concerning the molecular biologyof viral infection
  • Growth of several classes of analgesics
  • Intricate chemical structure of steroids
  • Development of compounds designed to lower cholesterol
  • Discovery of COX-2 nonsteroidal anti-inflammatory drugs(NSAIDs)
  • Research and development of oral contraceptives

The text ends with an overview of the many steps required beforea drug may be approved by the U. S. Food and DrugAdministration.

Lavishly illustrated with chemical structures, and supplementedby an appendix for those readers who need assistance ininterpreting the structures, the text is highly suited for studentsin medicinal chemistry, as well as for researchers inpharmaceuticals and medical practitioners in search of new insightsinto drug synthesis and discovery.

About the Author:

DANIEL LEDNICER, PhD, is the acclaimed author of several books on drug synthesis and discovery. His career in both the private and public sectors has been devoted to the search for new therapeutic agents. Dr. Lednicer spent two decades at the bench as a chemist at the Upjohn Company. Following that, he served as director of chemical research at Mead Johnson, director of pharmaceutical sciences at Adria Laboratories, and pharmaceutical manager at Analytical Biochemistry Laboratories. Most recently, he was a project officer at the National Cancer Institute.

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