Dynamic Combinatorial Chemistry: In Drug Discovery, Bioorganic Chemistry, and Materials Science

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9780470096031: Dynamic Combinatorial Chemistry: In Drug Discovery, Bioorganic Chemistry, and Materials Science
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Effective techniques for applying Dynamic CombinatorialChemistry

In a relatively short period, Dynamic Combinatorial Chemistry(DCC) has grown from proof-of-concept experiments in a few isolatedlabs to a broad conceptual framework with applications to anexceptional range of problems in molecular recognition, leadcompound identification, catalyst design, nanotechnology, polymerscience, and others. Bringing together a group of respectedexperts, this overview explains how chemists can apply DCC andfragment-based library methods to lead generation for drugdiscovery and molecular recognition in bioorganic chemistry andmaterials science.

Chapters cover:

  • Basic theory

  • Approaches to binding in proteins and nucleic acids

  • Molecular recognition

  • Self-sorting

  • Catalyst discovery

  • Materials discovery

  • Analytical chemistry challenges

A comprehensive, single-source reference about DCC methods andapplications including aspects of fragment-based drug discovery,this is a core reference that will spark the development of newsolutions and strategies for chemists building structure librariesand designing compounds and materials.

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About the Author:

Benjamin L. Miller is an Associate Professor of Dermatology, Biomedical Engineering, and Biochemistry and Biophysics at the University of Rochester. In addition to his academic credentials, Dr. Miller has industry consulting experience as the founder of Adarza BioSystems and Lighthouse Biosciences.

Review:

"The book edited by Benjamin Miller ... open[s] new horizonsshowing the first steps from molecular to nanolevel functionalobjects. These steps are sometime too long and the researchstrategies should expand the fundamental understanding of complexdynamic structures and properties as it relates to creatingproducts and manufacturing processes.... Within this context, thisbook covers the most essential discoveries in DCC during the lastdecade. DCC employing evolutional approaches to produce chemicaldiversity is expressing a strong fundamental basis which certainlywill serve for the development of the next generation of DynamicConstitutional Systems.... The DCC general principles described inthis book and their further elaboration will be guidelines for suchfuture developments. Key questions concerning basic principles andrelated approaches that have been used in Dynamic combinatorialchemistry in order to control the evolution of dynamic systems areclearly presented by the selected topics of this book. The mostrevolutionary consequences may reflect the fascinatingpossibilities offered by selection, evolution, amplification andreplication processes."
Dr. Mihai Barboiu, Institut Européen desMembranes, Adaptive Supramolecular Nanosystems Group IEM/UMII

"This book makes an outstanding reference book for molecularrecognition, physical organic, pharmaceutical, and supramolecularchemists. It has enough information for one to learn and startpracticing in the field, but is also sophisticated enough for theexpert to use learn the approaches of their colleagues. Dr. Millerhas done an excellent job of bringing the DCC field together in acohesive and educational fashion. I recommend the bookenthusiastically."
Dr. Eric V. Anslyn, The University of Texas

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Book Description John Wiley and Sons Ltd, United States, 2009. Hardback. Condition: New. 1. Auflage. Language: English . Brand New Book. This book presents an overview of dynamic combinatorial chemistry (DCC) and fragment-based library methods and how chemists apply them to the problems of lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science. Chapters cover basic theory, approaches to binding in proteins and small molecules, molecular recognition, catalyst discovery, click chemistry, SAR by NMR, and analytical chemistry challenges. A single-source reference about modern methods in fragment-based drug discovery and DCC methods and applications, this is a core resource for chemists building structure libraries and designing compounds. Seller Inventory # AAH9780470096031

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Book Description John Wiley and Sons Ltd, United States, 2009. Hardback. Condition: New. 1. Auflage. Language: English . Brand New Book. This book presents an overview of dynamic combinatorial chemistry (DCC) and fragment-based library methods and how chemists apply them to the problems of lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science. Chapters cover basic theory, approaches to binding in proteins and small molecules, molecular recognition, catalyst discovery, click chemistry, SAR by NMR, and analytical chemistry challenges. A single-source reference about modern methods in fragment-based drug discovery and DCC methods and applications, this is a core resource for chemists building structure libraries and designing compounds. Seller Inventory # AAH9780470096031

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