Introduction to Modern Liquid Chromatography

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9780470167540: Introduction to Modern Liquid Chromatography
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The latest edition of the authoritative reference to HPLC

High-performance liquid chromatography (HPLC) is today theleading technique for chemical analysis and related applications,with an ability to separate, analyze, and/or purify virtually anysample. Snyder and Kirkland's Introduction to Modern LiquidChromatography has long represented the premier reference toHPLC. This Third Edition, with John Dolan as added coauthor,addresses important improvements in columns and equipment, as wellas major advances in our understanding of HPLC separation, ourability to solve problems that were troublesome in the past, andthe application of HPLC for new kinds of samples.

This carefully considered Third Edition maintains thestrengths of the previous edition while significantly modifying itsorganization in light of recent research and experience. The textbegins by introducing the reader to HPLC, its use in relation toother modern separation techniques, and its history, then leadsinto such specific topics as:

  • The basis of HPLC separation and the general effects ofdifferent experimental conditions
  • Equipment and detection
  • The column—the "heart" of the HPLC system
  • Reversed-phase separation, normal-phase chromatography,gradient elution, two-dimensional separation, and othertechniques
  • Computer simulation, qualitative and quantitative analysis, andmethod validation and quality control
  • The separation of large molecules, including both biologicaland synthetic polymers
  • Chiral separations, preparative separations, and samplepreparation
  • Systematic development of HPLC separations—new to thisedition
  • Troubleshooting tricks, techniques, and case studies for bothequipment and chromatograms
Designed to fulfill the needs of the full range of HPLC users, fromnovices to experts, Introduction to Modern LiquidChromatography, Third Edition offers the most up-to-date,comprehensive, and accessible survey of HPLC methods andapplications available.

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About the Author:

Lloyd R. Snyder, PhD, is a Principal at LC Resources inWalnut Creek, California. He is the author or coauthor of severalbooks including An Introduction to Separation Science, Introductionto Modern Liquid Chromatography, Second Edition, the bestsellingPractical HPLC Method Development, Second Edition, and thecomprehensive High-Performance Gradient Elution, all published byWiley.

Joseph J. Kirkland, PhD, is Vice President of Researchand Development for Advanced Materials Technology, Inc., andcoauthor of Introduction to Modern Liquid Chromatography, SecondEdition, Practical HPLC Method Development, Second Edition, andModern Size-Exclusion Liquid Chromatography, Second Edition, allpublished by Wiley.

John W. Dolan, PhD, is a Principal at LC Resources. He isauthor of the popular "LC Troubleshooting" column in LCGC magazineand coauthor with Lloyd Snyder of Troubleshooting LC Systems andHigh-Performance Gradient Elution.

Review:

"In summary, I would strongly recommend this book for anyoneworking with LC and LC/MS. It is a finely crafted introduction thatadequately covers nearly every aspect of the science. The emphasison basic principles and practical aspects ensures that it will be auseful reference for many years to come." (J Am Soc Mass Spectrom,2011)

"This third edition is highly cross-referenced, so as to allowthe reader to follow up on topics of special interest, or toclarify questions that may arise during reading. The third editionof Introduction to Modern Liquid Chromatography will continue to bethe HPLC reference book for thousands of readers, eitherexperienced workers who may wish to explore topics of his/herchoice, or find an answer to specific problems, or beginners whowould like to understand and know the possibilities offered bythe
technique." (Chemistry Journals, 11 April 2011)

"This classic text on liquid chromatography has been thoroughlyupdated through the addition of information on moderninstrumentation, columns, and troubleshooting. It is a valuableresource for practicing chromatographers at all levels.." (AnalBioanal Chem, 2011)

"In summary, I would strongly recommend this book for anyoneworking with LC and LC/MS. It is a finely crafted introduction thatadequately covers nearly every aspect of the science. The emphasison basic principles and practical aspects ensures that it will be auseful reference for any years to come." (American Society for MassSpectrometry, 21 Januay 2011)

"The text is illustrated with many figures and tablesoriginating from authors' own work or taken from the literature . .. both groups of readers will find in this book plenty ofinformation and inspiration." (Journal of Separation Science, 1June 2010)

"Following their highly successful second edition (1979), whichappeared more than 30 years ago, Snyder (LC Resources) and Kirkland(Advanced Materials Technology) have teamed with Dolan (LCResources) and additional collaborators to provide an excellentupdate of their earlier work." (CHOICE, July 2010)

"It is difficult in these times to ever call a scientific book a"bargain", but this truly is. The wealth of information containedin these almost 1000 pages is invaluable. The book iscomprehensive, eminently readable and approachable, and highlyuseful for both the skilled chromatographer and those new to thetechnique. Everyone using a liquid chromatographic instrument wouldbenefit from owning a copy." (JACS, 2010)

"It's current, clearly-indexed, well-referenced, andcomprehensive. The inclusion of John Dolan as author hassignificantly expanded the sections on troubleshooting, andadditional expert contributors have enhanced the coverage of thespecialist chapters." - Bruce Hamilton posted on the ChromatographyForum

 

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Other Popular Editions of the Same Title

9780471038221: Introduction to Modern Liquid Chromatography

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ISBN 10:  0471038229 ISBN 13:  9780471038221
Publisher: Wiley-Interscience, 1979
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9780471810193: Introduction to Modern Liquid Chromatography

John W..., 1974
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